Xi-Shan Cao, Chang-Mei Feng, Li Yan, Lei Zhang, Wei Jiao, Mei-Ying Wang, Wen-Qi Zheng, Zhi-De Hu
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引用次数: 0
Abstract
Background: Several studies have evaluated the diagnostic accuracy of pleural fluid carbohydrate antigen 72-4 (CA72-4) for malignant pleural effusion (MPE), but the results were diverse. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of pleural fluid CA72-4 for MPE.
Methods: The PubMed and Web of Science databases were searched to verify potential studies investigating the diagnostic accuracy of pleural fluid CA72-4 for MPE. The last search date was August 2024. The quality of the eligible studies was assessed by this study using the revised diagnostic accuracy study quality assessment tool-2 to assess the quality of the eligible studies. This study used a summary receiver operating characteristic (sROC) curve and a bivariate model to pool the findings and their 95% confidence intervals (CIs) of available studies.
Results: Eight studies with 828 cases of MPEs and 963 cases of benign pleural effusion (BPE) were included in the present meta-analysis. The pooled sensitivity (95% CI) and specificity (95% CI) were 0.47 (0.39-0.55) and 0.98 (0.95-0.99). The area under sROC curves was 0.77 (95% CI: 0.73-0.80). The primary design weaknesses of the included studies were the representativeness of the participants and the data-driven threshold to define positive CA72-4. A significant publication bias was observed across the eligible studies.
Conclusions: Pleural fluid CA72-4 is an auxiliary diagnostic marker for MPE. However, its diagnostic accuracy may be overestimated by available studies.
期刊介绍:
Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.