The efficacy and safety of the addition of programmed cell death protein 1 inhibitor to preoperative chemotherapy in locoregionally advanced oropharyngeal carcinoma.

IF 1.5 4区 医学 Q4 ONCOLOGY
Translational cancer research Pub Date : 2025-02-28 Epub Date: 2025-02-26 DOI:10.21037/tcr-2025-202
Guan-Zhong Lu, Zhi-Cong Hong, Yi-Feng Yu, Lin-Feng Guo, Daniel T Ginat, San-Gang Wu, Li-Mei Guan
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引用次数: 0

Abstract

Background: Immune checkpoint inhibitors have shown promise in improving the survival rates for recurrent and/or metastatic head and neck cancers. However, their impact on curative outcomes in head and neck cancers remains undefined, especially for those with locoregionally advanced oropharyngeal carcinoma (LAOPC), a subtype of head-and-neck malignancy closely associated with human papillomavirus infection. This study aimed to clarify the efficacy and safety of the addition of programmed cell death protein 1 (PD-1) inhibitor into preoperative chemotherapy in LAOPC.

Methods: We retrospectively included patients with LAOPC who underwent preoperative immunochemotherapy between 2021 and 2024. Statistical analyses were conducted using chi-square tests. The efficacy was assessed using Response Evaluation Criteria in Solid Tumors (RECIST; version 1.1). Safety was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) 5.0.

Results: A total of 23 patients were identified, and 11 (47.8%) had P16-positive tumors. There were 22 patients (95.7%) who completed two cycles of preoperative treatment. Among the 23 patients, the response to primary tumors and neck metastatic lymph nodes could be assessed in 21 and 22 patients, respectively. Additionally, 13 (61.9%) patients had a major pathologic response to the primary tumor, including 12 patients (57.1%) who achieved a pathologic complete response (PCR). In addition, 11 (50.0%) patients had a PCR in the metastatic cervical lymph nodes, while 11 (50.0%) patients still had residual tumors in the lymph nodes. The combined positive score and P16 status were not significantly associated with PCR to the primary tumor or neck metastatic lymph nodes. Moreover, 19 (82.6%) patients experienced treatment-related adverse effects, with the majority being grade 1-2 toxicities, and only 2 (8.7%) patients had grade 3 or higher toxicities. No treatment-related deaths occurred.

Conclusions: The incorporation of a PD-1 inhibitor into preoperative chemotherapy may be an effective approach for treating LAOPC and involve acceptable toxicity.

局部晚期口咽癌术前化疗中加入程序性细胞死亡蛋白1抑制剂的疗效和安全性。
背景:免疫检查点抑制剂在提高复发和/或转移性头颈癌的生存率方面显示出希望。然而,它们对头颈部癌症疗效的影响仍不明确,特别是对那些局部区域晚期口咽癌(LAOPC)的患者,这是一种与人乳头瘤病毒感染密切相关的头颈部恶性肿瘤亚型。本研究旨在阐明在LAOPC术前化疗中加入程序性细胞死亡蛋白1 (PD-1)抑制剂的有效性和安全性。方法:我们回顾性地纳入了2021年至2024年间接受术前免疫化疗的LAOPC患者。采用卡方检验进行统计分析。采用实体肿瘤疗效评价标准(RECIST;版本1.1)。安全性采用不良事件通用术语标准(CTCAE) 5.0进行评估。结果:共发现23例患者,其中11例(47.8%)为p16阳性肿瘤。22例患者(95.7%)完成了2个周期的术前治疗。在23例患者中,分别有21例和22例患者对原发肿瘤和颈部转移淋巴结的反应可以评估。此外,13例(61.9%)患者对原发肿瘤有主要病理反应,其中12例(57.1%)患者达到病理完全缓解(PCR)。此外,11例(50.0%)患者在转移的颈部淋巴结中有PCR, 11例(50.0%)患者在淋巴结中仍有肿瘤残留。合并阳性评分和P16状态与PCR对原发肿瘤或颈部转移淋巴结无显著相关性。此外,19例(82.6%)患者出现了治疗相关的不良反应,其中大多数为1-2级毒性,只有2例(8.7%)患者出现了3级或更高的毒性。无治疗相关死亡发生。结论:术前化疗联合PD-1抑制剂可能是治疗LAOPC的有效方法,且毒性可接受。
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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
252
期刊介绍: Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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