Cryoablation for breast cancer: a narrative review of advances, clinical applications, and future challenges.

IF 1.5 4区 医学 Q4 ONCOLOGY
Translational cancer research Pub Date : 2025-02-28 Epub Date: 2025-02-26 DOI:10.21037/tcr-24-1415
Manchen Yang, Baosan Han, Ping Ye
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引用次数: 0

Abstract

Background and objective: Breast cancer remains one of the most common malignant tumors affecting women, with its incidence continuing to rise in recent years. Cryoablation, a minimally invasive technique, has emerged as a promising alternative to conventional surgical excision. Its advantages include high precision, rapid recovery, suitability for local anesthesia, and the potential to activate the immune system, making it an appealing option for patients who are either unwilling or unable to undergo conventional surgical procedures. The objective of this narrative review is to assess the progress and current status of cryoablation in the treatment of breast cancer, providing a comprehensive overview of its technological advances and clinical applications, including device development, mechanisms, surgical procedures, indications, and clinical outcomes for different tumour types. In addition, the article discusses the use of cryoablation in combination with immunotherapy and the challenges ahead.

Methods: This study conducted a literature review by searching the PubMed and Web of Science databases to identify the latest research findings in the field of cryoablation technology and breast cancer treatment. Based on these findings, a narrative review was generated.

Key content and findings: This article presents the mechanisms, devices, and surgical procedures of cryoablation, affirming its safety and efficacy in the clinical treatment of breast cancer. Additionally, it explores the challenges associated with combining cryoablation with immunotherapy to prevent tumor recurrence. As technological advancements continue, it is anticipated that more extensive clinical trials will be conducted to validate the broader application of cryoablation in breast cancer treatment, addressing the limitations of currently available small-scale studies. This progress will aid in selecting more effective treatment strategies for breast cancer patients.

Conclusions: Cryoablation has been proven to be a unique and effective approach for treating early-stage, advanced, and inoperable breast cancer patients, demonstrating favorable therapeutic outcomes. Additionally, cryoablation can enhance anti-tumor immune responses, and its combination with immunotherapy and nanomedicine shows promise in preventing tumor recurrence. As a result, cryoablation is gradually becoming a viable alternative to traditional surgical methods for breast cancer treatment.

冷冻消融治疗乳腺癌:进展、临床应用和未来挑战的叙述性回顾。
背景和目的:乳腺癌仍然是影响妇女的最常见的恶性肿瘤之一,近年来其发病率持续上升。冷冻消融是一种微创技术,已成为传统手术切除的一种有希望的替代方法。它的优点包括高精度、快速恢复、适合局部麻醉和激活免疫系统的潜力,使其成为不愿或无法接受传统外科手术的患者的一个有吸引力的选择。这篇叙述性综述的目的是评估冷冻消融在乳腺癌治疗中的进展和现状,提供其技术进步和临床应用的全面概述,包括设备开发、机制、外科手术、适应症和不同肿瘤类型的临床结果。此外,本文还讨论了冷冻消融联合免疫治疗的应用以及未来的挑战。方法:本研究通过检索PubMed和Web of Science数据库进行文献综述,获取冷冻消融技术与乳腺癌治疗领域的最新研究成果。根据这些调查结果,进行了叙述性审查。主要内容和发现:本文介绍了冷冻消融的机制、设备和手术方法,肯定了其在乳腺癌临床治疗中的安全性和有效性。此外,它还探讨了将冷冻消融与免疫治疗相结合以预防肿瘤复发的挑战。随着技术的不断进步,预计将进行更广泛的临床试验,以验证冷冻消融在乳腺癌治疗中的更广泛应用,解决目前可用的小规模研究的局限性。这一进展将有助于为乳腺癌患者选择更有效的治疗策略。结论:冷冻消融已被证明是治疗早期、晚期和不能手术的乳腺癌患者的一种独特而有效的方法,具有良好的治疗效果。此外,冷冻消融可以增强抗肿瘤免疫反应,并与免疫治疗和纳米药物联合使用,在预防肿瘤复发方面有希望。因此,冷冻消融正逐渐成为传统手术治疗乳腺癌的可行替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
252
期刊介绍: Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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