Cryoablation for breast cancer: a narrative review of advances, clinical applications, and future challenges.

IF 1.5 4区 医学 Q4 ONCOLOGY
Translational cancer research Pub Date : 2025-02-28 Epub Date: 2025-02-26 DOI:10.21037/tcr-24-1415
Manchen Yang, Baosan Han, Ping Ye
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引用次数: 0

Abstract

Background and objective: Breast cancer remains one of the most common malignant tumors affecting women, with its incidence continuing to rise in recent years. Cryoablation, a minimally invasive technique, has emerged as a promising alternative to conventional surgical excision. Its advantages include high precision, rapid recovery, suitability for local anesthesia, and the potential to activate the immune system, making it an appealing option for patients who are either unwilling or unable to undergo conventional surgical procedures. The objective of this narrative review is to assess the progress and current status of cryoablation in the treatment of breast cancer, providing a comprehensive overview of its technological advances and clinical applications, including device development, mechanisms, surgical procedures, indications, and clinical outcomes for different tumour types. In addition, the article discusses the use of cryoablation in combination with immunotherapy and the challenges ahead.

Methods: This study conducted a literature review by searching the PubMed and Web of Science databases to identify the latest research findings in the field of cryoablation technology and breast cancer treatment. Based on these findings, a narrative review was generated.

Key content and findings: This article presents the mechanisms, devices, and surgical procedures of cryoablation, affirming its safety and efficacy in the clinical treatment of breast cancer. Additionally, it explores the challenges associated with combining cryoablation with immunotherapy to prevent tumor recurrence. As technological advancements continue, it is anticipated that more extensive clinical trials will be conducted to validate the broader application of cryoablation in breast cancer treatment, addressing the limitations of currently available small-scale studies. This progress will aid in selecting more effective treatment strategies for breast cancer patients.

Conclusions: Cryoablation has been proven to be a unique and effective approach for treating early-stage, advanced, and inoperable breast cancer patients, demonstrating favorable therapeutic outcomes. Additionally, cryoablation can enhance anti-tumor immune responses, and its combination with immunotherapy and nanomedicine shows promise in preventing tumor recurrence. As a result, cryoablation is gradually becoming a viable alternative to traditional surgical methods for breast cancer treatment.

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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
252
期刊介绍: Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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