Multifaceted role of transgelin isoforms in cancer hallmarks.

IF 3.3 3区 医学 Q2 ONCOLOGY
Ana Maria Jimenez Jimenez, Yazan Haddad, Vendula Jemelikova, Vojtech Adam, Miguel Angel Merlos Rodrigo
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引用次数: 0

Abstract

Transgelins (TAGLNs) are actin-binding proteins within the calponin family, playing a crucial role in modulating actin-myosin interactions and maintaining actin filament stability. These proteins are expressed in both smooth and non-smooth muscle cells, contributing to the regulation of muscle contractility and cell migration. TAGLNs family has three isoforms that differ in their isoelectric point, namely: TAGLN1, TAGLN2, and TAGLN3. TAGLNs regulation is involved in the development of many diseases, such as pulmonary arterial hypertension, asthma, atherosclerosis, obstructive nephropathy, diabetes, and cancer. Recent research indicates TAGLNs involvement in carcinogenesis and chemoresistance. This review investigates TAGLNs as potential cancer biomarkers, exploring their versatile tissue-specific impact on patient outcomes. We also highlight their roles as, tumor suppressor agents and tumor progression oncogenes depending on the tumor type, tumor genetic variations and TAGLNs expression profiles. Furthermore, emerging evidence suggests that the interplay between TAGLN2 and chemoresistance to anticancer drugs is mediated by its interaction with the chemoresistance double agent MT-2, with possible bidirectional implications. TAGLNs present a promising avenue for novel therapeutic strategies against cancer, owing to their tissue-specific duality in promoting/suppressing tumor growth and cell migration in cancer cells. Thus, they can serve as a potential prognostic/diagnostic biomarker. The focus should be on leveraging, in future therapeutics, the interplay between TAGLNs and MTs to reverse tumor progression and chemoresistance, transforming them into tumor suppression.

transgelin异构体在癌症标志中的多方面作用。
Transgelins (TAGLNs)是钙钙蛋白家族中的肌动蛋白结合蛋白,在调节肌动蛋白-肌球蛋白相互作用和维持肌动蛋白丝稳定性方面起着至关重要的作用。这些蛋白在平滑肌和非平滑肌细胞中均有表达,参与肌肉收缩性和细胞迁移的调节。TAGLNs家族有三个等电点不同的同工异构体,分别是TAGLN1、TAGLN2和TAGLN3。TAGLNs的调控参与了许多疾病的发展,如肺动脉高压、哮喘、动脉粥样硬化、阻塞性肾病、糖尿病和癌症。最近的研究表明,TAGLNs参与癌变和化疗耐药。本综述研究了TAGLNs作为潜在的癌症生物标志物,探索其对患者预后的多种组织特异性影响。我们还强调了它们作为肿瘤抑制因子和肿瘤进展癌基因的作用,这取决于肿瘤类型、肿瘤遗传变异和TAGLNs的表达谱。此外,新出现的证据表明,TAGLN2与抗癌药物化疗耐药之间的相互作用是通过其与化疗耐药双重剂MT-2的相互作用介导的,可能具有双向意义。由于TAGLNs在促进/抑制肿瘤生长和癌细胞迁移方面具有组织特异性的双重特性,因此它为抗癌的新治疗策略提供了一条有希望的途径。因此,它们可以作为潜在的预后/诊断生物标志物。在未来的治疗方法中,重点应该是利用TAGLNs和MTs之间的相互作用来逆转肿瘤进展和化疗耐药,将其转化为肿瘤抑制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Carcinogenesis
Carcinogenesis 医学-肿瘤学
CiteScore
9.20
自引率
2.10%
发文量
95
审稿时长
1 months
期刊介绍: Carcinogenesis: Integrative Cancer Research is a multi-disciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer in man. The journal publishes papers that warrant prompt publication in the areas of Biology, Genetics and Epigenetics (including the processes of promotion, progression, signal transduction, apoptosis, genomic instability, growth factors, cell and molecular biology, mutation, DNA repair, genetics, etc.), Cancer Biomarkers and Molecular Epidemiology (including genetic predisposition to cancer, and epidemiology), Inflammation, Microenvironment and Prevention (including molecular dosimetry, chemoprevention, nutrition and cancer, etc.), and Carcinogenesis (including oncogenes and tumor suppressor genes in carcinogenesis, therapy resistance of solid tumors, cancer mouse models, apoptosis and senescence, novel therapeutic targets and cancer drugs).
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