Association between the triglyceride glucose index and the risk of acute respiratory failure in patients with acute pancreatitis.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2025-03-18 DOI:10.1186/s12876-025-03771-9

Jiao Lv, Yuanjun Zhou, Changyan Tao, Yan Cai, Hongfeng Yang, Juan Xu, Jun Chen, Ruxian Sun

{"title":"Association between the triglyceride glucose index and the risk of acute respiratory failure in patients with acute pancreatitis.","authors":"Jiao Lv, Yuanjun Zhou, Changyan Tao, Yan Cai, Hongfeng Yang, Juan Xu, Jun Chen, Ruxian Sun","doi":"10.1186/s12876-025-03771-9","DOIUrl":null,"url":null,"abstract":"Background: The triglyceride glucose (TyG) index serves as a dependable marker for insulin resistance and has shown a significant correlation with the severity of acute pancreatitis (AP). However, no research exists regarding the association between the TyG index and the development of acute respiratory failure (ARF) in AP. This study assesses the association between TyG index and ARF in patients with AP.Methods: Retrospective cohort analysis was conducted with the MIMIC-IV 2.2 critical care data. The endpoint focused on ARF during hospitalization. Statistical analysis encompassed univariate and multivariate logistic regressions, alongside restricted cubic spline (RCS) analysis to explore potential nonlinear associations. Receiver operating characteristic (ROC) curve analysis was employed to identify the optimal TyG index cutoff, leading to the classification of patients into Low TyG and High TyG groups. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were subsequently applied to minimize the influence of confounding factors, thereby further clarifying the relationship between the TyG index and ARF in patients with AP.Results: A total of 758 patients were involved in this study, the incidence of ARF was 21.64%. Logistic regression analyses demonstrated a significant association between the TyG index and the incidence of ARF in patients with AP. The RCS model illustrated a nonlinear relationship between a higher TyG index and an increased risk of ARF. The cutoff value of TyG index was 9.099 for ARF in patients with AP based on the ROC curve analysis. Furthermore, following PSM and IPTW, multivariate logistic regression analysis indicated that the High TyG group exhibited a significantly higher risk of ARF compared to the Low TyG group (P < 0.05).Conclusions: The TyG index is associated with ARF risk in AP patients and may aid in early risk assessment.","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"182"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916307/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12876-025-03771-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The triglyceride glucose (TyG) index serves as a dependable marker for insulin resistance and has shown a significant correlation with the severity of acute pancreatitis (AP). However, no research exists regarding the association between the TyG index and the development of acute respiratory failure (ARF) in AP. This study assesses the association between TyG index and ARF in patients with AP.

Methods: Retrospective cohort analysis was conducted with the MIMIC-IV 2.2 critical care data. The endpoint focused on ARF during hospitalization. Statistical analysis encompassed univariate and multivariate logistic regressions, alongside restricted cubic spline (RCS) analysis to explore potential nonlinear associations. Receiver operating characteristic (ROC) curve analysis was employed to identify the optimal TyG index cutoff, leading to the classification of patients into Low TyG and High TyG groups. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were subsequently applied to minimize the influence of confounding factors, thereby further clarifying the relationship between the TyG index and ARF in patients with AP.

Results: A total of 758 patients were involved in this study, the incidence of ARF was 21.64%. Logistic regression analyses demonstrated a significant association between the TyG index and the incidence of ARF in patients with AP. The RCS model illustrated a nonlinear relationship between a higher TyG index and an increased risk of ARF. The cutoff value of TyG index was 9.099 for ARF in patients with AP based on the ROC curve analysis. Furthermore, following PSM and IPTW, multivariate logistic regression analysis indicated that the High TyG group exhibited a significantly higher risk of ARF compared to the Low TyG group (P < 0.05).

Conclusions: The TyG index is associated with ARF risk in AP patients and may aid in early risk assessment.

查看原文本刊更多论文

甘油三酯葡萄糖指数与急性胰腺炎患者急性呼吸衰竭风险的关系

背景：甘油三酯葡萄糖（TyG）指数是胰岛素抵抗的可靠指标，与急性胰腺炎（AP）的严重程度有显著相关性。然而，TyG指数与AP患者急性呼吸衰竭（ARF）发生之间的关系尚无相关研究。本研究评估AP患者TyG指数与ARF的关系。方法：采用MIMIC-IV 2.2重症监护数据进行回顾性队列分析。终点集中在住院期间的ARF。统计分析包括单变量和多变量逻辑回归，以及限制三次样条（RCS）分析，以探索潜在的非线性关联。采用受试者工作特征（ROC）曲线分析确定最佳TyG指数截止点，将患者分为低TyG组和高TyG组。采用倾向评分匹配（PSM）和治疗加权逆概率（IPTW）来减少混杂因素的影响，从而进一步明确ap患者TyG指数与ARF的关系。结果：本研究共纳入758例患者，ARF发生率为21.64%。Logistic回归分析显示，TyG指数与AP患者ARF发生率之间存在显著相关性。RCS模型显示，TyG指数越高，ARF风险越高，两者之间存在非线性关系。根据ROC曲线分析，AP患者ARF的TyG指数临界值为9.099。此外，在PSM和IPTW后，多因素logistic回归分析显示，TyG高组发生ARF的风险明显高于TyG低组(P结论：TyG指数与AP患者ARF风险相关，可能有助于早期风险评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.