Somayeh Yaslianifard, Fatemeh Sameni, Kimia Kazemi, Yousef Atefpour, Bahareh Hajikhani, Ali Baradaran Bagheri, Shahrooz Yazdani, Masoud Dadashi
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引用次数: 0
Abstract
Background: Helicobacter pylori (H. pylori) is known to induce chronic inflammatory conditions, and interactions between the host immune system and pathogen have diverted attention toward investigating its correlation with extra-gastrointestinal disorders.
Objective: The present study aimed to assess the rate of H. pylori infection in cardiovascular disease (CVD) through a systematic review and meta-analysis.
Methods: We conducted a large-scale meta-analysis to determine the prevalence rates of H. pylori infection in vascular diseases. Articles from PubMed/Medline, Web of Science, and Embase databases published between 2000 and 2023 were included for analysis. We used multiple independent observers to extract data, calculated the pooled frequency of H. pylori in vascular diseases using a random effect model, and reported the results as a weighted average based on the study population. The main outcome measures were presented with 95% confidence intervals (CI).
Results: In 87 included studies, the prevalence of H. pylori infection in vascular diseases was 56.7% worldwide. 14.25% of H. pylori isolates harbored the cagA gene. The predominant vascular complication was coronary artery disease (CAD) (31.07%), primarily documented in Europe. This meta-analysis revealed a declining emphasis on studying the association of H. pylori infection with vascular disease in recent times.
Conclusion: According to this meta-analysis, H. pylori infection has a high frequency in CVD and may increase the risk of vascular diseases. However, further research is required, particularly in nations with limited data.
背景：已知幽门螺杆菌（h.p ylori）可诱导慢性炎症，宿主免疫系统和病原体之间的相互作用已将注意力转移到研究其与胃肠道外疾病的相关性上。目的：本研究旨在通过系统回顾和荟萃分析评估心血管疾病（CVD）幽门螺杆菌感染率。方法：我们进行了一项大规模荟萃分析，以确定血管疾病中幽门螺杆菌感染的患病率。2000年至2023年间发表的来自PubMed/Medline、Web of Science和Embase数据库的文章被纳入分析。我们使用多个独立观测者提取数据，使用随机效应模型计算幽门螺杆菌在血管疾病中的合并频率，并以研究人群为基础的加权平均值报告结果。主要结果测量以95%置信区间（CI）表示。结果：在87项纳入的研究中，幽门螺杆菌在血管疾病中的感染率为56.7%。14.25%的幽门螺杆菌含有cagA基因。主要的血管并发症是冠状动脉疾病（CAD）（31.07%），主要记录在欧洲。这项荟萃分析显示，近年来对幽门螺杆菌感染与血管疾病的相关性研究的重视程度有所下降。结论：本荟萃分析显示，幽门螺杆菌感染在心血管疾病中发生率较高，并可能增加血管疾病的发生风险。然而，需要进一步的研究，特别是在数据有限的国家。
期刊介绍：
Annals of Clinical Microbiology and Antimicrobials considers good quality, novel and international research of more than regional relevance. Research must include epidemiological and/or clinical information about isolates, and the journal covers the clinical microbiology of bacteria, viruses and fungi, as well as antimicrobial treatment of infectious diseases.
Annals of Clinical Microbiology and Antimicrobials is an open access, peer-reviewed journal focusing on information concerning clinical microbiology, infectious diseases and antimicrobials. The management of infectious disease is dependent on correct diagnosis and appropriate antimicrobial treatment, and with this in mind, the journal aims to improve the communication between laboratory and clinical science in the field of clinical microbiology and antimicrobial treatment. Furthermore, the journal has no restrictions on space or access; this ensures that the journal can reach the widest possible audience.
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