Correction: myCAF-derived Exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment

Abstract

Correction: Journal of Hematology & Oncology (2024) 17:126

https://doi.org/10.1186/s13045-024-01643-5

The authors wish to note a correction to an error in Figure 7F (LvPWAR6 group).

Due to the large number of serial sections of images, one section from the Control group was unintentionally mistakenly placed as the representative figure of the experimental group (LvPWAR6 group) in Fig. 7F. After carefully reviewing the original experimental records and raw data, the authors confirm that this was an unintentional error.

Fig. 1

Experimental records of the NK1.1 immunofluorescence experiment

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The authors conducted three repeat experiments of NK1.1 immunofluorescence for Fig. 7F and all of them reached the similar conclusion.

Fig. 2

Three repetitions of the immunofluorescence experiment

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The authors would like to emphasize that this error does not impact the scientific conclusions of the article, since the conclusion of Fig. 7F has been validated and supported by the results of the flow cytometry experiments in Fig. 7C-D. The NK1.1 immunofluorescence experiment of Fig.7 F was conducted merely as a further confirmation of the conclusion from Fig. 7C-D.

Fig. 3

Corrected image for figure 7F in the original article

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The authors also sincerely apologize for an incorrect image had been inadvertently included in Supplementary Figure 3D (DLD1/myCAFs group, transwell assay).

The authors provide the corrected image for the Supplementary Figure 3D (Figure 4 in this article) as well as the original experimental records and results from three repeated experiments for it (Figure 5 and Figure 6 respectively in this correction article).

Fig. 4

Corrected supplementary figure 3De

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The three repeated experiments of DLD1 transwell assays for Supplementary Figure 3D all reached the similar conclusion.

Fig. 5

Experimental records of transwell assay

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The authors wish to emphasise that this error was unintentional and does not impact the scientific conclusions of the article since the conclusion has also been validated in Supplementary Figure 3D/Spheroid formation assay and Supplementary Figure 3G (HCT116 transwell/Spheroid formation assay).

Fig. 6

Three biological records of supplementary Figure 3D

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In addition, the authors have also carefully reviewed the other raw data and did not find any other issues in our published article.

Authors and Affiliations

1. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

   Hongsheng Fang, Weixing Dai, Ruiqi Gu, Yanbo Zhang, Jin Li, Wenqin Luo, Lingyu Han, Yichao Wang, Chengyao Jiang, Renjie Wang & Guoxiang Cai

2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

   Hongsheng Fang, Weixing Dai, Ruiqi Gu, Yanbo Zhang, Jin Li, Wenqin Luo, Shanyou Tong, Lingyu Han, Yichao Wang, Chengyao Jiang, Renjie Wang & Guoxiang Cai

3. Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

   Shanyou Tong

4. Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

   Xue Wang

Authors

1. Hongsheng FangView author publications

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2. Weixing DaiView author publications

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3. Ruiqi GuView author publications

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4. Yanbo ZhangView author publications

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5. Jin LiView author publications

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6. Wenqin LuoView author publications

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7. Shanyou TongView author publications

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8. Lingyu HanView author publications

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9. Yichao WangView author publications

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10. Chengyao JiangView author publications

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11. Xue WangView author publications

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12. Renjie WangView author publications

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13. Guoxiang CaiView author publications

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Corresponding authors

Correspondence to Xue Wang, Renjie Wang or Guoxiang Cai.

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Fang, H., Dai, W., Gu, R. et al. Correction: myCAF-derived Exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment. J Hematol Oncol 18, 31 (2025). https://doi.org/10.1186/s13045-025-01685-3

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• Published: 18 March 2025

• DOI: https://doi.org/10.1186/s13045-025-01685-3

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