A follow-up Study of Effect of PDE5i Drugs on Extended High-frequency Hearing.

IF 0.6 Q4 SURGERY

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI:10.1007/s12070-025-05372-0

Chandrahas Chandanshive, R Rangasayee

{"title":"A follow-up Study of Effect of PDE5i Drugs on Extended High-frequency Hearing.","authors":"Chandrahas Chandanshive, R Rangasayee","doi":"10.1007/s12070-025-05372-0","DOIUrl":null,"url":null,"abstract":"<p><p>Phosphodiesterase type 5 inhibitors (PDE5i), such as Sildenafil (Viagra), Tadalafil (Cialis), and Vardenafil (Levitra), are commonly used to treat erectile dysfunction (ED) and other conditions like pulmonary hypertension and benign prostatic hyperplasia. While their therapeutic effects are well-documented, limited research exists on their potential ototoxicity. Some studies suggest that PDE5i drugs may impact hearing, potentially through the alteration of the nitric oxide pathway, which is crucial for cochlear function. Extended High-frequency audiometry (EHFA) has proven sensitive in detecting ototoxicity, making it a valuable tool for evaluating drug-induced hearing loss.The study involved 60 participants, 30 in the observational group (PDE5i users) and 30 in the control group (healthy individuals). Pre- and post-medication EHFA revealed that the observational group had significantly poorer hearing thresholds than the control group both before and after taking PDE5i drugs. The results showed that the pre-medication hearing thresholds of the observational group were already impaired, suggesting a pre-existing sensitivity to hearing loss. Post-medication, there was further deterioration in hearing thresholds.The study found that PDE5i users exhibited significantly poorer hearing sensitivity, even before taking the medication, possibly due to underlying hearing issues associated with erectile dysfunction. While the findings indicate potential ototoxic effects, further research is needed to confirm these results and explore the long-term impact. Close monitoring of hearing sensitivity in PDE5i users is recommended.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1537-1541"},"PeriodicalIF":0.6000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909369/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Otolaryngology and Head and Neck Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12070-025-05372-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/13 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Phosphodiesterase type 5 inhibitors (PDE5i), such as Sildenafil (Viagra), Tadalafil (Cialis), and Vardenafil (Levitra), are commonly used to treat erectile dysfunction (ED) and other conditions like pulmonary hypertension and benign prostatic hyperplasia. While their therapeutic effects are well-documented, limited research exists on their potential ototoxicity. Some studies suggest that PDE5i drugs may impact hearing, potentially through the alteration of the nitric oxide pathway, which is crucial for cochlear function. Extended High-frequency audiometry (EHFA) has proven sensitive in detecting ototoxicity, making it a valuable tool for evaluating drug-induced hearing loss.The study involved 60 participants, 30 in the observational group (PDE5i users) and 30 in the control group (healthy individuals). Pre- and post-medication EHFA revealed that the observational group had significantly poorer hearing thresholds than the control group both before and after taking PDE5i drugs. The results showed that the pre-medication hearing thresholds of the observational group were already impaired, suggesting a pre-existing sensitivity to hearing loss. Post-medication, there was further deterioration in hearing thresholds.The study found that PDE5i users exhibited significantly poorer hearing sensitivity, even before taking the medication, possibly due to underlying hearing issues associated with erectile dysfunction. While the findings indicate potential ototoxic effects, further research is needed to confirm these results and explore the long-term impact. Close monitoring of hearing sensitivity in PDE5i users is recommended.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.80

自引率

0.00%

发文量

226

审稿时长

6-12 weeks

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.