Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat's eyes.

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2025-03-15 DOI:10.4239/wjd.v16.i3.97336

Udomlak Matsathit, Manaras Komolkriengkrai, Wipapan Khimmaktong

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引用次数: 0

Abstract

Background: Small blood vessels in the eyes are more susceptible to injury, which can lead to complications. However, since diabetic retinopathy is often a serious clinical condition, most of this study focuses on the vascular system of the choroid. As part of this study, we looked at how gymnemic acid (from Gymnema sylvestre) and glabridin (from Glycyrrhiza glabra, or licorice) might help diabetic rats' choroid structural change and blood vessels.

Aim: To explore the effects of glabridin and gymnemic acid on the structural changes of the choroidal layer and choriocapillaris as well as the expression of vascular endothelial growth factor (VEGF) and cluster of differentiation (CD) 31 in diabetic rat's eye.

Methods: The male Wistar rats were separated into five groups: The control group (control), the diabetic group (DM), the diabetic rats treated with glabridin 40 mg/kg body weight (DM + GB), the diabetic rats treated with gymnemic acid 400 mg/kg body weight (DM + GM), and the diabetic rats treated with glyburide 4 mg/kg body weight (DM + GR).

Results: There was an increase in the thickness of both the choroid layer and the wall of the arteries in the DM. A decrease in vascularity and choroidal impairment was found in DM rats. After eight weeks of experimentation, the choroidal thickness increased, and the walls of choroid arteries. The choroidal thickness in the DM + GB was 15.69 ± 1.54 μm, DM + GM was 14.84 ± 1.31, and DM + GR groups was 16.45 ± 1.15 when compared with DM group (27.22 ± 2.05), the walls thickness of choroid arteries in the DM + GB was 10.23 ± 1.11, DM + GM was 10.41 ± 1.44, and DM + GR was 9.80 ± 1.78 when compared with DM group (16.35 ± 5.01), The expression of VEGF and CD31 was lower compared to the DM group.

Conclusion: In diabetic choroidopathy, hyperglycemia and inflammation cause damage to the neurovascular unit and blood-retinal barrier. Anti-VEGF treatments can slow or reverse the progression of the disease. According to current research findings, glabridin and gymnemic acid can reduce damage to the choroid, which is a factor that can sometimes result in vision loss.

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光甘草定和裸子酸减轻糖尿病大鼠眼脉络膜结构改变和绒毛膜毛细血管损伤。

背景：眼部的小血管更容易受到损伤，这可能导致并发症。然而，由于糖尿病视网膜病变通常是一种严重的临床疾病，因此大多数研究都集中在脉络膜的血管系统上。作为这项研究的一部分，我们研究了裸子酸（来自木门草）和光甘草定（来自甘草）如何帮助糖尿病大鼠的脉络膜结构改变和血管。目的：探讨光甘草定和裸子酸对糖尿病大鼠眼脉络膜层和绒毛膜毛细血管结构变化及血管内皮生长因子（VEGF）和分化簇（CD） 31表达的影响。方法：将雄性Wistar大鼠分为5组：对照组（control）、糖尿病组（DM）、光甘草定40 mg/kg体重组（DM + GB）、裸子子酸400 mg/kg体重组（DM + GM）、格列本脲4 mg/kg体重组（DM + GR）。结果：DM大鼠血管脉络膜层和动脉壁厚度均增加，血管功能减少，脉络膜损伤明显。经过8周的实验，脉络膜厚度增加，脉络膜动脉壁。DM + GB的脉络膜的厚度为15.69±1.54μm, DM +通用为14.84±1.31,和DM + GR组为16.45±1.15相比,DM组(27.22±2.05),脉络膜动脉壁厚度的DM + GB为10.23±1.11,DM +通用为10.41±1.44,和DM + GR为9.80±1.78相比,DM组(16.35±5.01),VEGF的表达和CD31相比DM组低。结论：糖尿病脉络膜病变中，高血糖和炎症可引起神经血管单位和血视网膜屏障的损害。抗vegf治疗可以减缓或逆转疾病的进展。根据目前的研究发现，光甘草定和裸子酸可以减少对脉络膜的损伤，这是一个有时会导致视力丧失的因素。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.