{"title":"Sexual Dimorphisms in Endocrinopathies: Their Impact on the Evolution of Metabolic Diseases.","authors":"Chitralekha Kataki","doi":"10.1016/j.mce.2025.112521","DOIUrl":null,"url":null,"abstract":"<p><p>Sexual dimorphisms, the biological differences between males and females, are well-documented across various endocrine disorders. These dimorphisms not only influence the presentation and progression of endocrinopathies but also play a critical role in the development and evolution of metabolic diseases. This review explores the intricate relationship between sexual dimorphisms and endocrinopathies such as Diabetes Mellitus, Thyroid disorder, Cushing's syndrome, Addison's disease, polycystic ovary syndrome (PCOS), Hypogonadism in males and acromegaly, and their subsequent effects on metabolic dysfunctions like insulin resistance, obesity, and cardiovascular diseases. By examining the hormonal, genetic, and environmental factors underlying these gender-specific differences, we aim to elucidate how sexual dimorphisms contribute to the disparate prevalence, clinical outcomes, and treatment responses observed in metabolic disorders. This review highlights the significance of considering sexual dimorphisms in advancing the understanding of metabolic diseases.</p>","PeriodicalId":18707,"journal":{"name":"Molecular and Cellular Endocrinology","volume":" ","pages":"112521"},"PeriodicalIF":3.8000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and Cellular Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.mce.2025.112521","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Sexual dimorphisms, the biological differences between males and females, are well-documented across various endocrine disorders. These dimorphisms not only influence the presentation and progression of endocrinopathies but also play a critical role in the development and evolution of metabolic diseases. This review explores the intricate relationship between sexual dimorphisms and endocrinopathies such as Diabetes Mellitus, Thyroid disorder, Cushing's syndrome, Addison's disease, polycystic ovary syndrome (PCOS), Hypogonadism in males and acromegaly, and their subsequent effects on metabolic dysfunctions like insulin resistance, obesity, and cardiovascular diseases. By examining the hormonal, genetic, and environmental factors underlying these gender-specific differences, we aim to elucidate how sexual dimorphisms contribute to the disparate prevalence, clinical outcomes, and treatment responses observed in metabolic disorders. This review highlights the significance of considering sexual dimorphisms in advancing the understanding of metabolic diseases.
期刊介绍：
Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.
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