Sexual dimorphisms in endocrinopathies: Their impact on the evolution of metabolic diseases

IF 3.8 3区医学 Q2 CELL BIOLOGY

Molecular and Cellular Endocrinology Pub Date : 2025-03-15 DOI:10.1016/j.mce.2025.112521

Chitralekha Kataki

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Abstract

Sexual dimorphisms, the biological differences between males and females, are well-documented across various endocrine disorders. These dimorphisms not only influence the presentation and progression of endocrinopathies but also play a critical role in the development and evolution of metabolic diseases. This review explores the intricate relationship between sexual dimorphisms and endocrinopathies such as Diabetes Mellitus, Thyroid disorder, Cushing's syndrome, Addison's disease, polycystic ovary syndrome (PCOS), Hypogonadism in males and acromegaly, and their subsequent effects on metabolic dysfunctions like insulin resistance, obesity, and cardiovascular diseases. By examining the hormonal, genetic, and environmental factors underlying these gender-specific differences, we aim to elucidate how sexual dimorphisms contribute to the disparate prevalence, clinical outcomes, and treatment responses observed in metabolic disorders. This review highlights the significance of considering sexual dimorphisms in advancing the understanding of metabolic diseases.

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内分泌疾病中的两性异形：它们对代谢性疾病进化的影响。

两性二态性，即男性和女性之间的生物学差异，在各种内分泌疾病中都有很好的记录。这些二态性不仅影响内分泌疾病的表现和进展，而且在代谢性疾病的发生演变中起着关键作用。本文综述了两性异形与糖尿病、甲状腺疾病、库欣综合征、艾迪生病、多囊卵巢综合征（PCOS）、男性性腺功能减退和肢端肥大症等内分泌疾病之间的复杂关系，以及它们对胰岛素抵抗、肥胖和心血管疾病等代谢功能障碍的影响。通过检查这些性别差异背后的激素、遗传和环境因素，我们旨在阐明两性异形如何导致代谢性疾病中不同的患病率、临床结果和治疗反应。这篇综述强调了考虑两性异形在促进对代谢性疾病的理解中的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Endocrinology 医学-内分泌学与代谢

CiteScore

9.00

自引率

2.40%

发文量

174

审稿时长

42 days

期刊介绍： Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.