Disparities in the incidence, mortality and disability-adjusted life years of 33 early-onset cancer groups globally, 2012-2021: a systematic analysis.

IF 9.4 1区医学 Q1 HEMATOLOGY

Experimental Hematology & Oncology Pub Date : 2025-03-17 DOI:10.1186/s40164-025-00634-7

Wenxin Yan, Min Liu, Wenzhan Jing, Liangyu Kang, Ning Zhang, Haoran Sun, Jinyu He, Zhongdan Chen, Jue Liu, Wannian Liang, Jiahong Dong

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引用次数: 0

Abstract

Background: The global cancer burden is rising, with early-onset cancers becoming more prevalent. We aimed to investigate the burden, trend and population disparity in 33 early-onset cancers from 2012 to 2021.

Methods: Annual incidence, death, and disability-adjusted life years (DALY) numbers and rates for early-onset (15-49 years) cancer groups were calculated from Global Burden of Diseases (GBD) 2021 dataset, covering 2012-2021 across global, five SDI groupings, and 204 countries and territories. Estimated annual percentage change (EAPC) in the incidence, mortality and DALY rates was calculated to quantify temporal trends, while spearman correlation analysis was used to examine the correlation between rates, EAPC and SDI.

Results: In 2021, there were 2.65 million new early-onset cancer cases excluding non-melanoma skin cancer (NMSC), resulting in 0.99 million deaths and 50.7 million DALYs. Breast, tracheal, bronchus and lung (TBL), cervical, colon and stomach cancers were the leading causes of DALYs. The DALY rate for early-onset cancer excluding NMSC changed from 65.7 million in 2012 to 67.0 million in 2021, with an estimated annual percentage change (EAPC) of -0.49%. While the DALY rate plateaued for females, it decreased by -0.95% for males. Ten of 33 cancer groups exhibited an EAPC > 0. The high SDI quintile had 1,100 DALYs per 100,000 caused by early-onset cancers excluding NMSC, with the highest declining trend in DALY and mortality rates, while the high-middle SDI quintile had the highest early-onset mortality rates. Rising trends in cancer incidence and mortality were especially notable among females in the middle, low-middle, and low SDI quintiles.

Conclusion: The global burden of early-onset cancer differs significantly by SDI quintile and gender. The increasing burden across multiple cancer groups poses a significant public health challenge. The rising burden of multiple cancer types is alarming, highlighting the need for increased policy support and targeted medical assistance to address the disparities in their impact.

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2012-2021年全球33个早发性癌症组发病率、死亡率和残疾调整生命年差异的系统分析

背景：全球癌症负担正在上升，早发性癌症变得越来越普遍。我们的目的是调查2012 - 2021年33种早发性癌症的负担、趋势和人口差异。方法：从全球疾病负担（GBD） 2021数据集中计算早发（15-49岁）癌症组的年发病率、死亡和残疾调整生命年（DALY）数字和发病率，涵盖2012-2021年全球、5个SDI分组和204个国家和地区。计算发病率、死亡率和DALY率的估计年百分比变化（EAPC）以量化时间趋势，而spearman相关分析用于检查发病率、EAPC和SDI之间的相关性。结果：2021年，除非黑色素瘤皮肤癌（NMSC）外，有265万例新发早发癌症病例，导致99万例死亡和5070万例DALYs。乳腺癌、气管、支气管和肺癌（TBL）、宫颈癌、结肠癌和胃癌是DALYs的主要原因。不包括NMSC的早发性癌症的DALY率从2012年的6570万变化到2021年的6700万，估计年百分比变化（EAPC）为-0.49%。虽然女性的DALY率趋于稳定，但男性的DALY率下降了-0.95%。33个癌症组中有10个显示EAPC bb0。高SDI五分之一组的早发性癌症（不包括NMSC）每10万人中有1100例DALY， DALY和死亡率下降趋势最高，而高中等SDI五分之一组的早发性死亡率最高。在中、中、低SDI五分位数的女性中，癌症发病率和死亡率的上升趋势尤为显著。结论：全球早发性癌症负担在SDI五分位数和性别上存在显著差异。多个癌症群体日益增加的负担构成了重大的公共卫生挑战。多种癌症日益增加的负担令人震惊，突出表明需要增加政策支持和有针对性的医疗援助，以解决其影响的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Hematology & Oncology Medicine-Oncology

CiteScore

12.60

自引率

7.30%

发文量

审稿时长

6 weeks

期刊介绍： Experimental Hematology & Oncology is an open access journal that encompasses all aspects of hematology and oncology with an emphasis on preclinical, basic, patient-oriented and translational research. The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings. Experimental Hematology & Oncology publishes original work, hypothesis, commentaries and timely reviews. With open access and rapid turnaround time from submission to publication, the journal strives to be a hub for disseminating new knowledge and discussing controversial topics for both basic scientists and busy clinicians in the closely related fields of hematology and oncology.