Medical comorbidities in adults newly diagnosed with multiple sclerosis and clinically isolated syndrome: An observational study exploring prevalence, risk factors, and outcomes

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-03-16 DOI:10.1016/j.msard.2025.106390

Sydney J. Pattison , Erin G. Mistretta , Dawn M. Ehde , Anna L. Kratz , Kevin N. Alschuler

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引用次数: 0

Abstract

Background

Comorbidity is common in people with MS (PwMS) and clinically isolated syndrome (CIS), but research exploring factors associated with comorbidity and impacts on health outcomes in newly diagnosed PwMS and CIS is limited. This study aimed to (1) report the prevalence of medical comorbidities in newly diagnosed PwMS and CIS, (2) explore the relationship between comorbidity and demographic factors, (3) examine the relationship between comorbidities and outcomes one year following diagnosis, accounting for baseline outcomes to assess change over time, and (4) explore if these relationships differ with comorbidity treatment.

Methods

Secondary analysis of data collected from a longitudinal, observational study of adults newly diagnosed with MS or CIS 1 month and 12 months after diagnosis (N = 230). Statistical methods included point biserial, Chi-squared, ANCOVA, and multivariate linear regression.

Results

The most common comorbidities within the first year following diagnosis were mental health (32.9 %), vascular (32 %), neurological (22.5 %), and musculoskeletal (9.1 %). Age and race were associated with hypertension and heart trouble, respectively. After one year, mental health comorbidity was associated with higher fatigue scores, musculoskeletal and neurological comorbidity with higher pain interference, and neurological comorbidity with less exercise, after accounting baseline for fatigue, pain interference and exercise. Those with treated neurological conditions had worse pain interference compared to those with untreated conditions.

Conclusions

Mental health, neurological, and musculoskeletal comorbidities were common within the first year following diagnosis, and were associated with worse fatigue and pain, and decreased exercise. Future research should explore how early treatment of comorbidities may impact outcomes and disease progression.

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新诊断为多发性硬化症和临床孤立综合征的成人的医学合并症：一项探索患病率、危险因素和结果的观察性研究

背景：合并症在多发性硬化症（PwMS）和临床孤立综合征（CIS）患者中很常见，但新诊断的PwMS和CIS患者合并症的相关因素和对健康结果的影响的研究有限。本研究旨在(1)报告新诊断的PwMS和CIS的医疗合并症的患病率，(2)探讨合并症与人口统计学因素之间的关系，(3)检查合并症与诊断后一年结局之间的关系，计算基线结局以评估随时间的变化，以及(4)探讨这些关系是否因合并症治疗而不同。方法对新诊断为MS或CIS的成人在诊断后1个月和12个月（N = 230）的纵向观察研究收集的数据进行二次分析。统计方法包括点双列、卡方、ANCOVA和多元线性回归。结果诊断后一年内最常见的合并症是精神健康（32.9%）、血管（32%）、神经（22.5%）和肌肉骨骼（9.1%）。年龄和种族分别与高血压和心脏病有关。一年后，在计算了疲劳、疼痛干扰和运动的基线后，心理健康共病与较高的疲劳评分相关，肌肉骨骼和神经共病与较高的疼痛干扰相关，神经共病与较少的运动相关。与未接受治疗的患者相比，接受治疗的神经系统疾病患者的疼痛干扰更严重。结论心理健康、神经系统和肌肉骨骼合并症在诊断后的一年内很常见，并与更严重的疲劳和疼痛以及运动减少有关。未来的研究应该探索早期治疗合并症如何影响预后和疾病进展。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.