Electroencephalography in Preterm Infants for Predicting Neurodevelopmental Outcomes: A Systematic Review and Diagnostic Test Accuracy Meta-Analysis

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Pediatric neurology Pub Date : 2025-02-27 DOI:10.1016/j.pediatrneurol.2025.02.010

Vijay Kumar Krishnegowda DrNB , Prathik Bandiya DM , Tapas Bandyopadhyay DM , Haribalakrishna Balasubramanian DM , Daniele Trevisanuto MD , Viraraghavan Vadakkencherry Ramaswamy DM

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引用次数: 0

Abstract

Background

Electroencephalography (EEG) and amplitude-integrated EEG (aEEG) have been utilized to predict neurodevelopmental impairment (NDI) in preterm infants.

Methods

MEDLINE, SCOPUS, Embase, Web of Science, and Cochrane Library were searched from inception until November 1, 2023. Observational studies evaluating EEG and aEEG and neurodevelopment assessment performed at least after six months corrected age (CA) were included. A diagnostic test accuracy (DTA) meta-analysis using a Bayesian random-effects bivariate model was performed. QUADAS-2 was used to assess the risk of bias, and GRADE approach was used to ascertain the certainty of evidence.

Results

Thirty-eight studies (n = 4667) were included in the systematic review of which 26 studies (n = 3363) were synthesized in a DTA meta-analysis. EEG and aEEG had a sensitivity of 63.9% (95% credible intervals [CrI]: 52.1%, 76.3%) and specificity of 87.6% (80.9%, 94.1%) for the outcome of any NDI (<1 S.D. from the mean value for the CA). For the outcome of severe NDI (<2 S.D.s from the mean value for the CA) (10 studies, n = 1075), the sensitivity was 59.7% (42.3%, 75.9%) and specificity was 85.2% (72.7%, 92.4%). Evidence certainty was very low to low. Subgroup analysis of studies that had utilized Bayley Scales of Infant and Toddler Development between 18 and 30 months CA (12 studies, n = 1202) for neurodevelopmental assessment revealed a sensitivity of 59% (42.3%, 74.7%) and specificity of 83.7% (75.8%, 90.1%) for any NDI.

Conclusion

EEG and aEEG possibly have suboptimal sensitivity and an acceptable-to-high specificity in predicting any NDI and severe NDI in preterm infants.

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.