Emerging role of macrophages in neuropathic pain

IF 5.9 1区医学 Q1 ORTHOPEDICS

Journal of Orthopaedic Translation Pub Date : 2025-03-01 DOI:10.1016/j.jot.2025.01.016

Si-Han Tong , De-Lin Liu , Peng Liao , Sen-Yao Zhang , Jian Zhou , Yao Zong , Chang-Qing Zhang , Yi-Gang Huang , Jun-Jie Gao

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Abstract

Neuropathic pain is a complex syndrome caused by injury to the neurons, which causes persistent hypersensitivity and considerable inconvenience to the patient's whole life. Over the past two decades, the interaction between immune cells and neurons has been proven to play a crucial role in the development of neuropathic pain. Increasing studies have indicated the important role of macrophages for neuroinflammation and have shed light on the underlying molecular and cellular mechanisms. In addition, novel therapeutic methods targeting macrophages are springing up, which provide more options in our clinical treatment. Herein, we reviewed the characteristics of peripheral macrophages and their function in neuropathic pain, with the aim of better understanding how these cells contribute to pathological processes and paving the way for therapeutic approaches.

Translational potential statement

This review provides a comprehensive overview of the mechanisms underlying the interplay between the macrophages and nervous system during the progression of nerve injury. Additionally, it compiles existing intervention strategies targeting macrophages for the treatment of neuropathic pain. This information offers valuable insights for researchers seeking to address the challenge of this intractable pain.

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巨噬细胞在神经性疼痛中的新作用

神经性疼痛是一种由神经元损伤引起的复杂综合征，可引起持续性超敏反应，给患者的一生带来相当大的不便。在过去的二十年中，免疫细胞和神经元之间的相互作用已被证明在神经性疼痛的发展中起着至关重要的作用。越来越多的研究表明巨噬细胞在神经炎症中的重要作用，并揭示了潜在的分子和细胞机制。此外，针对巨噬细胞的新型治疗方法不断涌现，为我们的临床治疗提供了更多的选择。在此，我们回顾了外周巨噬细胞的特征及其在神经性疼痛中的功能，旨在更好地了解这些细胞如何参与病理过程并为治疗方法铺平道路。本文综述了巨噬细胞与神经系统在神经损伤过程中相互作用的机制。此外，它还汇编了针对巨噬细胞治疗神经性疼痛的现有干预策略。这一信息为研究人员寻求解决这一顽固性疼痛的挑战提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Orthopaedic Translation Medicine-Orthopedics and Sports Medicine

CiteScore

11.80

自引率

13.60%

发文量

审稿时长

29 days

期刊介绍： The Journal of Orthopaedic Translation (JOT) is the official peer-reviewed, open access journal of the Chinese Speaking Orthopaedic Society (CSOS) and the International Chinese Musculoskeletal Research Society (ICMRS). It is published quarterly, in January, April, July and October, by Elsevier.