Early-Life Risks of Central Precocious Puberty.

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-03-14 DOI:10.1016/j.eprac.2025.03.004

Wei-Jou Yin, Jhih-Wei Hsu, Chun-Chang Chen, Emily Chia-Yu Su, San-Yuan Wang, Yan-Jen Chen, Yang-Ching Chen

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引用次数: 0

Abstract

Objectives: To investigate the factors in early life that may contribute to central precocious puberty (CPP).

Methods: The study utilized data from the Taiwan Puberty Longitudinal Study, including 2241 children under pubertal assessment and a questionnaire of risk factors. We analyzed associations using the Fitting Generalized Linear Models in R (R Core Team, 2023), with R studio (Posit, 2023) version 4.3.1.

Results: Among the 2241 children examined, 745 had CPP. Overall, higher gestational weight gain (GWG) increased the risk of CPP (odds ratio [OR]: 1.03, 95% CI: 1.01-1.05); while higher GWG served as a protective factor in females (OR: 0.97, 95% CI: 0.95-0.99). Maternal gestational diabetes mellitus (GDM) also increased the CPP risk, particularly in males (OR: 2.66, 95% CI: 1.00-7.25). Longer exclusive breastfeeding was linked to lower CPP risk overall (OR: 0.96, 95% CI: 0.93-1.00) but was not significant when analyzed by gender.

Conclusions: Higher maternal GWG was associated with an increased risk of CPP overall, while GWG became negatively associated with CPP, only in females. Maternal GDM was linked to a higher risk of CPP, particularly in males. The duration of exclusive breastfeeding was inversely correlated with CPP risk, but this effect was not significant when analyzed by gender.

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中枢性性早熟的生命早期风险。

目的：探讨早期生活中可能导致中枢性性早熟（CPP）的因素。方法：利用台湾省青春期纵向研究（TPLS）的数据，对2241名儿童进行青春期评估和危险因素问卷调查。结果：在2241名接受检查的儿童中，有745名患有CPP。总体而言，较高的妊娠体重增加（GWG）增加了CPP的风险（OR: 1.03, 95% CI: 1.01-1.05）；而较高的GWG是女性的保护因素（OR: 0.97, 95% CI: 0.95-0.99）。母体妊娠期糖尿病（GDM）也增加了CPP的风险，尤其是男性（OR: 2.66, 95% CI: 1.00-7.25）。较长的纯母乳喂养（EBF）总体上与较低的CPP风险相关（OR: 0.96, 95% CI: 0.93-1.00），但在性别分析时并不显著。结论：较高的母体GWG总体上与CPP风险增加相关，而GWG仅在女性中与CPP呈负相关。母体GDM与CPP的高风险相关，尤其是男性。EBF持续时间与CPP风险呈负相关，但按性别分析，这种影响不显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.