Dmitry Molodenskiy, Valentin J Maurer, Dingquan Yu, Grzegorz Chojnowski, Stefan Bienert, Gerardo Tauriello, Konstantin Gilep, Torsten Schwede, Jan Kosinski
{"title":"AlphaPulldown2-a general pipeline for high-throughput structural modeling.","authors":"Dmitry Molodenskiy, Valentin J Maurer, Dingquan Yu, Grzegorz Chojnowski, Stefan Bienert, Gerardo Tauriello, Konstantin Gilep, Torsten Schwede, Jan Kosinski","doi":"10.1093/bioinformatics/btaf115","DOIUrl":null,"url":null,"abstract":"<p><strong>Summary: </strong>AlphaPulldown2 streamlines protein structural modeling by automating workflows, improving code adaptability, and optimizing data management for large-scale applications. It introduces an automated Snakemake pipeline, compressed data storage, support for additional modeling backends like UniFold and AlphaLink2, and a range of other improvements. These upgrades make AlphaPulldown2 a versatile platform for predicting both binary interactions and complex multi-unit assemblies.</p><p><strong>Availability and implementation: </strong>AlphaPulldown2 is freely available at https://github.com/KosinskiLab/AlphaPulldown.</p>","PeriodicalId":93899,"journal":{"name":"Bioinformatics (Oxford, England)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937959/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformatics (Oxford, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/bioinformatics/btaf115","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Summary: AlphaPulldown2 streamlines protein structural modeling by automating workflows, improving code adaptability, and optimizing data management for large-scale applications. It introduces an automated Snakemake pipeline, compressed data storage, support for additional modeling backends like UniFold and AlphaLink2, and a range of other improvements. These upgrades make AlphaPulldown2 a versatile platform for predicting both binary interactions and complex multi-unit assemblies.
Availability and implementation: AlphaPulldown2 is freely available at https://github.com/KosinskiLab/AlphaPulldown.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
