Analgesic and anti-inflammatory effects of chicken feet combined with traditional herbal medicines in acetic acid-induced mice and monosodium iodoacetate-induced osteoarthritis rats

IF 2.4 3区农林科学 Q3 FOOD SCIENCE & TECHNOLOGY

Food Science and Biotechnology Pub Date : 2025-01-06 DOI:10.1007/s10068-024-01766-y

Ji Yun Beak, Ki Sung Kang, Ah Young Lee, Hyun Young Kim

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Abstract

This study investigated the therapeutic efficacy of chicken feet combined with traditional herbal medicines widely used in Korea, Acanthopanax sessiliflorum Seeman and Eucommia ulmoides Oliver, in osteoarthritis (OA) progression. In this study, rats were administered chicken feet, A. sessiliflorum, and E. ulmoides mixture extracts (CAEM, 300 mg/kg) for 24 days after the monosodium iodoacetate (MIA) injection into the knee joints. CAEM significantly reduced the weight-bearing loss of the hind limb. In addition, Micro-CT imaging and histopathological analysis indicated that CAEM inhibited MIA-induced cartilage destruction, as evidenced by increased proteoglycan and decreased cartilage erosion. Western blot analysis showed that CAEM suppressed the inflammatory responses induced by MIA in knee cartilage tissue by regulating MAPK and NF-κB signaling pathways. Furthermore, CAEM treatment showed efficacy in suppressing the acetic acid-induced writhing response in mice. Therefore, CAEM may be helpful in relieving pain, alleviating cartilage degeneration, and inhibiting inflammatory responses in OA.

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来源期刊

Food Science and Biotechnology FOOD SCIENCE & TECHNOLOGY-

CiteScore

5.40

自引率

3.40%

发文量

174

审稿时长

2.3 months

期刊介绍： The FSB journal covers food chemistry and analysis for compositional and physiological activity changes, food hygiene and toxicology, food microbiology and biotechnology, and food engineering involved in during and after food processing through physical, chemical, and biological ways. Consumer perception and sensory evaluation on processed foods are accepted only when they are relevant to the laboratory research work. As a general rule, manuscripts dealing with analysis and efficacy of extracts from natural resources prior to the processing or without any related food processing may not be considered within the scope of the journal. The FSB journal does not deal with only local interest and a lack of significant scientific merit. The main scope of our journal is seeking for human health and wellness through constructive works and new findings in food science and biotechnology field.