Features of HLA-A*02 in Identifying Eligible Patients for Tecelra TCR-T Therapy.

IF 5.7 2区医学 Q1 Medicine

Cancer Science Pub Date : 2025-03-13 DOI:10.1111/cas.70048

Min Yang, Peiluan Zhong, Huifang Jiao, Pengcheng Wei

引用次数: 0

Abstract

This study investigates the molecular mechanisms behind HLA-A*02 subtypes' differential responses to Tecelra, a TCR-engineered T-cell therapy targeting MAGE-A4. Using computational tools, the study identifies specific HLA-A*02 alleles, such as HLA-A*02:07, HLA-A*02:05, and others, with low affinity for the GV10 peptide or a risk of inducing alloreactivity. These findings provide insights into patient selection for Tecelra therapy, suggesting exclusion criteria for certain HLA-A*02 subtypes to optimize treatment efficacy and minimize adverse reactions.

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HLA-A*02在确定Tecelra TCR-T治疗患者中的特征

本研究探讨了HLA-A*02亚型对靶向MAGE-A4的tcr工程t细胞疗法Tecelra差异反应的分子机制。利用计算工具，该研究鉴定了特异性HLA-A*02等位基因，如HLA-A*02:07、HLA-A*02:05等，这些等位基因对GV10肽的亲和力较低或有诱导同种异体反应的风险。这些发现为Tecelra治疗的患者选择提供了见解，建议排除某些HLA-A*02亚型以优化治疗效果并减少不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Science ONCOLOGY-

CiteScore

9.90

自引率

3.50%

发文量

406

审稿时长

17 weeks

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.