What is the research question? Estimands explained.

IF 5.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

European Journal of Endocrinology Pub Date : 2025-03-03 DOI:10.1093/ejendo/lvaf048

Rolf H H Groenwold, Saskia le Cessie, Olaf M Dekkers

引用次数: 0

Abstract

Although many papers of medical research report on a treatment effect, it is not always clear what is exactly meant by that effect. An estimand is a precise definition of a treatment effect and includes 5 attributes: population, treatment, (outcome) variable, intercurrent events, and summary measure. In this paper, we discuss how the estimand framework helps to align different phases of studies of medical treatments, from research objectives to design, conduct, analysis, and reporting of results.

查看原文本刊更多论文

研究问题是什么？Estimands解释道。

尽管许多医学研究论文报道了治疗效果，但并不总是清楚这种效果的确切含义。估计是治疗效果的精确定义，包括五个属性：人群、治疗、（结果）变量、交互事件和汇总测量。在本文中，我们讨论了评估框架如何帮助协调医学治疗研究的不同阶段，从研究目标到设计、实施、分析和报告结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Endocrinology 医学-内分泌学与代谢

CiteScore

9.80

自引率

3.40%

发文量

354

审稿时长

1 months

期刊介绍： European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.