N6-methyladenosine RNA modification in stomach carcinoma: Novel insights into mechanisms and implications for diagnosis and treatment

IF 4.2 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhengmao Lu , Zhaojie Lyu , Peixin Dong , Yunmei Liu , Lei Huang
{"title":"N6-methyladenosine RNA modification in stomach carcinoma: Novel insights into mechanisms and implications for diagnosis and treatment","authors":"Zhengmao Lu ,&nbsp;Zhaojie Lyu ,&nbsp;Peixin Dong ,&nbsp;Yunmei Liu ,&nbsp;Lei Huang","doi":"10.1016/j.bbadis.2025.167793","DOIUrl":null,"url":null,"abstract":"<div><div>N6-methyladenosine (m<sup>6</sup>A) RNA methylation is crucially involved in the genesis and advancement of gastric cancer (GC) by controlling various pathobiological aspects including gene expression, signal transduction, metabolism, cell death, epithelial-mesenchymal transition, angiogenesis, and exosome function. Despite its importance, the exact mechanisms by which m<sup>6</sup>A modification influences GC biology remain inadequately explored. This review consolidates the latest advances in uncovering the mechanisms and diverse roles of m<sup>6</sup>A in GC and proposes new research and translational directions. Key regulators (writers, readers, and erasers) of m<sup>6</sup>A, such as METTL3/14/16 and WTAP, significantly affect cancer progression, anticancer immune response, and treatment outcomes. m<sup>6</sup>A modification also impacts immune cell infiltration and the tumor microenvironment, highlighting its potential as a diagnostic and prognostic marker. Interactions between m<sup>6</sup>A methylation and non-coding RNAs offer further novel insights into GC development and therapeutic targets. Targeting m<sup>6</sup>A regulators could enhance immunotherapy response, overcome treatment resistance, and improve oncological and clinical outcomes. Models based on m<sup>6</sup>A can precisely predict treatment response and prognosis in GC. Additional investigation is needed to fully understand the mechanisms of m<sup>6</sup>A methylation and its potential clinical applications and relevance (e.g., as precise markers for early detection, prediction of outcome, and response to therapy and as therapeutic targets) in GC. Future research should focus on in vivo studies, potential clinical trials, and the examination of m<sup>6</sup>A modification in other types of cancers.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 5","pages":"Article 167793"},"PeriodicalIF":4.2000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. Molecular basis of disease","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0925443925001383","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

N6-methyladenosine (m6A) RNA methylation is crucially involved in the genesis and advancement of gastric cancer (GC) by controlling various pathobiological aspects including gene expression, signal transduction, metabolism, cell death, epithelial-mesenchymal transition, angiogenesis, and exosome function. Despite its importance, the exact mechanisms by which m6A modification influences GC biology remain inadequately explored. This review consolidates the latest advances in uncovering the mechanisms and diverse roles of m6A in GC and proposes new research and translational directions. Key regulators (writers, readers, and erasers) of m6A, such as METTL3/14/16 and WTAP, significantly affect cancer progression, anticancer immune response, and treatment outcomes. m6A modification also impacts immune cell infiltration and the tumor microenvironment, highlighting its potential as a diagnostic and prognostic marker. Interactions between m6A methylation and non-coding RNAs offer further novel insights into GC development and therapeutic targets. Targeting m6A regulators could enhance immunotherapy response, overcome treatment resistance, and improve oncological and clinical outcomes. Models based on m6A can precisely predict treatment response and prognosis in GC. Additional investigation is needed to fully understand the mechanisms of m6A methylation and its potential clinical applications and relevance (e.g., as precise markers for early detection, prediction of outcome, and response to therapy and as therapeutic targets) in GC. Future research should focus on in vivo studies, potential clinical trials, and the examination of m6A modification in other types of cancers.
N6-甲基腺苷(m6A)RNA 甲基化通过控制基因表达、信号转导、新陈代谢、细胞死亡、上皮-间质转化、血管生成和外泌体功能等各种病理生物学方面,在胃癌(GC)的发生和发展中起着至关重要的作用。尽管m6A修饰非常重要,但其影响GC生物学的确切机制仍未得到充分探索。这篇综述整合了揭示 m6A 在 GC 中的作用机制和多样性方面的最新进展,并提出了新的研究和转化方向。m6A的关键调控因子(书写者、阅读者和擦除者),如METTL3/14/16和WTAP,对癌症进展、抗癌免疫反应和治疗效果有显著影响。m6A修饰还影响免疫细胞浸润和肿瘤微环境,突出了其作为诊断和预后标志物的潜力。m6A 甲基化与非编码 RNA 之间的相互作用为 GC 的发展和治疗靶点提供了进一步的新见解。以 m6A 调节因子为靶点可以增强免疫治疗反应,克服治疗耐药性,改善肿瘤和临床预后。基于 m6A 的模型可以精确预测 GC 的治疗反应和预后。要全面了解 m6A 甲基化的机制及其在 GC 中的潜在临床应用和相关性(如作为早期检测、预后预测和治疗反应的精确标记以及作为治疗靶点),还需要进行更多的研究。未来的研究应重点关注体内研究、潜在的临床试验以及 m6A 修饰在其他类型癌症中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
12.30
自引率
0.00%
发文量
218
审稿时长
32 days
期刊介绍: BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信