Patient experiences with and adherence to Crohn's disease exclusion diet in Dutch Crohn's disease patients: a cohort study.

IF 3.9 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Therapeutic Advances in Gastroenterology Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.1177/17562848251323553

Fleur T R Wijers, Suzanne M C van Zundert, Charlotte M Verburgt, Nikki van der Kruk, Johan E Van Limbergen, Nicolette J Wierdsma

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引用次数: 0

Abstract

Background: Dietary therapy is commonly used as a treatment for Crohn's disease (CD). High dietary adherence is associated with achieving clinical remission. Crohn's disease exclusion diet (CDED) is a relatively new therapy in the management of CD.

Objective: This publication aims to assess the first real-life patient experience with and adherence to Crohn's disease exclusion diet plus partial enteral nutrition (CDED + PEN) in Dutch children and adults with mild-to-moderate CD.

Design: Interviews were performed with patients and/or caregivers prospectively after phases I, II, and III, and once after finishing therapy in a retrospective cohort.

Methods: We obtained data on patient experiences with CDED and the accompanying Modulife patient support platform and assessed effectiveness from patients' and physicians' perspectives based on medical and clinical data obtained from the patient file. The interview contained open questions, 5-point Likert scales, and Net Promotor Scores (NPS).

Results: Sixty-nine patients were included (52 pediatric and 17 adults). Approximately half of the patients in the prospective cohort and the majority (83%) of patients in the retrospective cohort would recommend CDED to others. Two-thirds of the patients would reconsider starting CDED again. A positive NPS (31) was given for recommending the support platform to others with the recipes feature as the most used and esteemed part. Median fecal calprotectin and C-reactive protein gradually decreased from baseline to 18 weeks of therapy in both children and adults. Two-thirds of the physicians assessed the diet as showing good effectiveness and would continue the dietary therapy at each phase of the diet.

Conclusion: Many mild-to-moderate active CD patients may experience positive outcomes and have good experiences with the CDED + PEN dietary therapy and the associated Modulife patient support platform. This study might add valuable patient perspectives to the growing clinical use of CDED in managing CD.

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荷兰克罗恩病患者克罗恩病排除饮食的患者经历和依从性：一项队列研究

背景：饮食疗法是克罗恩病（CD）的常用治疗方法。高饮食依从性与临床缓解有关。克罗恩病排他饮食（CDED）是一种相对较新的cd治疗方法。目的：本出版物旨在评估荷兰儿童和成人轻度至中度cd患者对克罗恩病排他饮食加部分肠内营养（CDED + PEN）的首次真实患者体验和依从性。设计：在1、2、3期和1期治疗结束后对患者和/或护理人员进行前瞻性访谈。方法：我们收集了CDED患者的经历以及随附的modlife患者支持平台的数据，并根据从患者档案中获得的医学和临床数据，从患者和医生的角度评估其有效性。访谈包括开放式问题、5分李克特量表和净发起人分数（NPS）。结果：纳入69例患者（52例儿童，17例成人）。大约一半的前瞻性队列患者和大多数（83%）的回顾性队列患者会向他人推荐CDED。三分之二的患者会重新考虑是否开始CDED。向他人推荐支持平台的NPS为正（31），其中食谱功能是最常用和最受尊敬的部分。在儿童和成人中，粪钙保护蛋白和c反应蛋白的中位数从基线到治疗18周逐渐下降。三分之二的医生认为这种饮食方法很有效并且会在每个阶段继续这种饮食疗法。结论：许多轻中度活动性CD患者在CDED + PEN饮食疗法和相关的modlife患者支持平台上可能会获得积极的结果和良好的体验。本研究可能为CDED在治疗CD中的临床应用提供有价值的患者观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.70

自引率

2.40%

发文量

103

审稿时长

15 weeks

期刊介绍： Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area. The editors welcome original research articles across all areas of gastroenterology and hepatology. The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.