Association of type 2 diabetes and osteoarthritis: an umbrella review of systematic reviews and meta-analyses.

IF 1.4 Q3 ORTHOPEDICS

European Journal of Orthopaedic Surgery and Traumatology Pub Date : 2025-03-12 DOI:10.1007/s00590-025-04231-6

Raju Vaishya, Anoop Misra, Mohit Kumar Patralekh, Pulkit Kalra, Abhishek Vaish, Filippo Migliorini

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引用次数: 0

Abstract

Introduction: An association between type 2 diabetes and osteoarthritis has been postulated. The present umbrella review of systematic reviews and meta-analyses investigated possible bidirectional relationships between type 2 diabetes and osteoarthritis.

Methods: PubMed, Scopus, Web of Science, and Cochrane Library databases were accessed. All the available systematic reviews and meta-analyses on the relationship between type 2 diabetes and osteoarthritis were accessed. The odds ratio (OR) effect measure and 95% confidence interval (CI) were used for the statistical analyses.

Results: Four systematic reviews, of whom three meta-analyses, were considered. Data from 26209 patients with osteoarthritis were considered: 3530 with type 2 diabetes and 22679 without type 2 diabetes. A significantly increased rate of osteoarthritis was evidenced in patients with type 2 diabetes than in patients without it (OR = 1.43; 95% CI 1.01 to 2.02). The effect persisted after in the subgroups age, sex, and obesity (pooled adjusted OR = 1.22; 95% CI 1.05 to 1.42).

Conclusion: Patients with type 2 diabetes might present an increased risk of developing osteoarthritis.

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来源期刊

European Journal of Orthopaedic Surgery and Traumatology 医学-整形外科

CiteScore

3.00

自引率

5.90%

发文量

265

审稿时长

3-8 weeks

期刊介绍： The European Journal of Orthopaedic Surgery and Traumatology (EJOST) aims to publish high quality Orthopedic scientific work. The objective of our journal is to disseminate meaningful, impactful, clinically relevant work from each and every region of the world, that has the potential to change and or inform clinical practice.