On arrival continuous brachial plexus block provides superior analgesia with reduced persistent postsurgical pain in complex hand injuries: A randomized controlled trial.

IF 2.9 2区 医学 Q2 CRITICAL CARE MEDICINE
Kajal Kashyap, Nidhi Bhatia, Kajal Jain, Karan Singla, Mandeep Kumar, Revathi Nair, Sunil Gaba, Tarush Gupta
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引用次数: 0

Abstract

Background: Patients with complex hand injuries experience extreme pain and frequently witness prolonged preoperative waiting period, which intensifies their agony, especially during wound dressing and debridement, further intensifying pain of acute trauma. Hence, there is a need to study utility of continuous peripheral nerve block in settings of acute trauma emergencies. We hypothesized that, as compared with intravenous systemic analgesics, continuous brachial plexus block would provide superior analgesia in these patients.

Methods: Eighty adults of either sex, with complex unilateral hand injuries (significant soft-tissue loss, crushed hand injury, and metacarpal bone fractures), having moderate-to-severe pain were randomized into two groups of 40 patients each. We excluded patients with sensory deficits, coagulopathy, or vascular injuries of the forearm. In the intervention group (group brachial plexus block [BPB]), patients received continuous infraclavicular brachial plexus block with 20 mL of 0.2% ropivacaine. In control group (group C) patients were administered intravenous analgesics (injection paracetamol [500 mg] 6 hourly with injection diclofenac [50 mg] 8 hourly). We recorded pain scores (Numeric Rating Scale) at regular intervals and total rescue analgesic used. Patients were followed-up on days 15 and 30 following surgery to note persistent postsurgical pain (PPSP). Groups were compared using Student's t test/χ 2 test as applicable. Mann-Whitney U test was used for statistical analysis of skewed continuous variables or ordered categorical data.

Results: Significantly more patients in group BPB reported Numeric Rating Scale score of <4, 1 hour following intervention (100% in group BPB vs. 57.5% in group C; p = 0.00). No patients in group BPB reported pain/discomfort during any interventions, like wound assessment/dressings. On the contrary, 55% (n = 22/40) of patients in group C experienced moderate-to-severe pain ( p = 0.00) and required rescue analgesic. The median preoperative waiting time was significantly less in group BPB (18 [16-18] vs. 48 [24-48] hours; p = 0.00). Significantly more patients in group C reported PPSP on days 15 and 30 (19/40 in group C vs. 6/40 in group BPB; p = 0.03).

Conclusion: On-arrival blocks with catheter technique provide consistent pain relief, with lower PPSP, and hence should be integrated in pain management protocols.

Level of evidence: Therapeutic/Care Management; Level II.

一项随机对照试验:到达后,连续臂丛阻滞提供了优越的镇痛效果,减少了复杂手部损伤术后持续疼痛。
背景:复杂手部损伤患者极度疼痛,术前等待时间往往延长,这加剧了患者的痛苦,尤其是在伤口敷料和清创过程中,进一步加剧了急性创伤的疼痛。因此,有必要研究连续周围神经阻滞在急性创伤紧急情况下的应用。我们假设,与静脉全身镇痛相比,持续的臂丛阻滞将为这些患者提供更好的镇痛效果。方法:80名患有复杂单侧手部损伤(严重软组织丢失、手部压伤和掌骨骨折)、中度至重度疼痛的成人(男女均可)随机分为两组,每组40名患者。我们排除了感觉缺陷、凝血功能障碍或前臂血管损伤的患者。干预组(臂丛阻滞组[BPB])患者接受持续锁骨下臂丛阻滞20 mL 0.2%罗哌卡因。对照组(C组)患者给予静脉镇痛(注射扑热息痛[500 mg] 6小时,注射双氯芬酸[50 mg] 8小时)。我们定期记录疼痛评分(数值评定量表)和使用的总抢救镇痛药。患者于术后第15天和第30天随访,观察持续性术后疼痛(PPSP)。组间比较采用Student’st检验/χ2检验。对偏态连续变量或有序分类数据的统计分析采用Mann-Whitney U检验。结果:BPB组患者报告的数值评定量表得分明显高于BPB组。结论:导管技术的到达阻滞提供一致的疼痛缓解,PPSP较低,因此应纳入疼痛管理方案。证据水平:治疗/护理管理;我水平。
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来源期刊
CiteScore
6.00
自引率
11.80%
发文量
637
审稿时长
2.7 months
期刊介绍: The Journal of Trauma and Acute Care Surgery® is designed to provide the scientific basis to optimize care of the severely injured and critically ill surgical patient. Thus, the Journal has a high priority for basic and translation research to fulfill this objectives. Additionally, the Journal is enthusiastic to publish randomized prospective clinical studies to establish care predicated on a mechanistic foundation. Finally, the Journal is seeking systematic reviews, guidelines and algorithms that incorporate the best evidence available.
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