Global Incidence, Risk Factors, and Temporal Trends of Adrenal Cancer: A Systematic Analysis of Cancer Registries.

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-03-10 DOI:10.1016/j.eprac.2025.03.002

Junjie Huang, Yat Ching Fung, Sze Chai Chan, Wing Sze Pang, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno Iii, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Claire Chenwen Zhong, Mellissa Withers, Martin C S Wong

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引用次数: 0

Abstract

Objective: Adrenal gland cancer (AGC) is a rare cancer with a poor prognosis. Studies on this cancer have been limited. This study, for the first time, aims to analyze the global disease burden and trends of AGC in country level and examine lifestyle and socioeconomic risk factors to generate hypotheses.

Methods: The Global Cancer Observatory database was used to extract the incidence rate of AGC in 2020. Age-standardized rates (ASRs) of AGC incidence and lifestyle/metabolic risk factor prevalence were obtained from databases. Linear regression and Joinpoint regression were used to assess associations with risk factors and Average Annual Percentage Change of AGC incidence.

Results: Globally, there were an estimated 16 961 new AGC cases in 2020 (ASR: 0.14 per 100 000 persons). Higher disease burden was observed mainly in European regions. ASRs were comparable between sexes (males: 0.16; females: 0.14). The higher ASR was observed among the older population aged 50 to 74 years with an ASR of 0.31 compared with the younger population aged 15 to 49 years with an ASR of 0.07. Higher AGC incidence was associated with higher Human Development Index, gross domestic product, and lifestyle-related factors such as physical inactivity, obesity, hypertension, and lipid disorder (β = 0.005-0.052).

Conclusion: The overall incidence trend showed a decrease, with 3 countries reporting significant decreases and 1 country reporting a significant increase. Similar patterns were observed by sex and age group, except for an overall increase among the younger population.

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肾上腺癌的全球发病率、危险因素和时间趋势：癌症登记的系统分析。

目的：肾上腺癌（AGC）是一种罕见的癌症，预后较差。对这种癌症的研究一直很有限。本研究首次旨在分析国家层面的全球肾上腺癌疾病负担和趋势，并检查生活方式和社会经济风险因素以产生假设。方法：利用全球癌症观测站（GLOBOCAN）数据库提取2020年肾上腺癌发病率。从数据库中获得AGC发病率的年龄标准化率（ASR）和生活方式/代谢危险因素患病率。采用线性回归和连接点回归评估危险因素和AGC发病率年平均百分比变化（AAPC）的相关性。结果：2020年全球估计有16961例新发AGC病例（ASR: 0.14 / 10万人）。较高的疾病负担主要发生在欧洲地区。ASRs在性别间具有可比性(男性：0.16；女性:0.14)。年龄较大的人群（50-74岁）的ASR为0.31，而年龄较小的人群（15-49岁）的ASR为0.07。较高的AGC发病率与较高的人类发展指数（HDI）、国内生产总值（GDP）和生活方式相关因素（如缺乏运动、肥胖、高血压和脂质紊乱）相关（β = 0.005 ~ 0.052）。结论：总体发病率呈下降趋势，3个国家报告显著下降，1个国家报告显著上升。在性别和年龄组中也观察到类似的模式，除了年轻人群的总体增长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.