The association between the dietary index for gut microbiota and non-alcoholic fatty liver disease and liver fibrosis: evidence from NHANES 2017-2020.

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Ce Zheng, Zeming Qi, Rui Chen, Zhixiong Liao, Lanfeng Xie, Fumang Zhang
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引用次数: 0

Abstract

Background: Imbalance in the gut microbiota is a key factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. The Dietary Index for Gut Microbiota (DI-GM) integrates the potential relationship between diet and gut microbiota diversity. This study aims to investigate the association between DI-GM and the risk of NAFLD and liver fibrosis, providing theoretical support for dietary intervention strategies.

Methods: This study utilized data from NHANES 2017-2020, including 6,181 eligible adult participants. The relationship between DI-GM and the risk of NAFLD and liver fibrosis was assessed using DI-GM quartiles, multivariate logistic regression, and restricted cubic spline (RCS) analysis. Subgroup analysis was performed to explore the predictive role of DI-GM in different populations. All analyses were weighted to ensure the representativeness of the results.

Results: DI-GM was negatively associated with the risks of NAFLD and liver fibrosis. As DI-GM scores increased, the risk of NAFLD and liver fibrosis significantly decreased (52.81%, 43.16%, 40.40%, and 31.98%, p < 0.05; 17.52%, 9.04%, 7.21%, and 6.78%, p < 0.05). Multivariate logistic regression analysis revealed that, in the unadjusted model (Model 1), for each unit increase in DI-GM, the risk of NAFLD decreased by 6.9% (OR = 0.931, 95% CI: 0.886-0.979, p < 0.001), while the risk of liver fibrosis decreased by 15.6% (OR = 0.844, 95% CI: 0.757-0.941, p < 0.05). In the quartile analysis, individuals in the highest DI-GM quartile (Q4) had a 58% lower risk of NAFLD compared to those in the lowest quartile (Q1) (OR = 0.42, 95% CI: 0.219-0.806, p < 0.001). The results remained significant even after adjusting for covariates. RCS analysis showed that DI-GM had a nonlinear relationship with the risks of NAFLD and liver fibrosis, with inflection points at scores of 2 and 5, indicating enhanced protective effects.

Conclusion: This study reveals a negative association between DI-GM and the risk of NAFLD and liver fibrosis, highlighting the potential role of healthy dietary patterns in the prevention and management of NAFLD and liver fibrosis through gut microbiota modulation, providing a theoretical basis for dietary interventions.

肠道微生物群饮食指数与非酒精性脂肪性肝病和肝纤维化之间的关系:来自NHANES 2017-2020的证据
背景:肠道菌群失衡是非酒精性脂肪性肝病(NAFLD)和肝纤维化发病的关键因素。肠道菌群日粮指数(DI-GM)综合了日粮与肠道菌群多样性之间的潜在关系。本研究旨在探讨DI-GM与NAFLD和肝纤维化风险的关系,为饮食干预策略提供理论支持。方法:本研究使用NHANES 2017-2020的数据,包括6181名符合条件的成人参与者。采用DI-GM四分位数、多变量logistic回归和限制性三次样条(RCS)分析评估DI-GM与NAFLD和肝纤维化风险之间的关系。亚组分析探讨DI-GM在不同人群中的预测作用。所有的分析都进行了加权,以确保结果的代表性。结果:DI-GM与NAFLD和肝纤维化风险呈负相关。随着DI-GM评分的增加,NAFLD和肝纤维化的风险显著降低(52.81%、43.16%、40.40%和31.98%)。p结论:本研究揭示了DI-GM与NAFLD和肝纤维化的风险呈负相关,突出了健康饮食模式通过调节肠道菌群在NAFLD和肝纤维化的预防和管理中的潜在作用,为饮食干预提供了理论依据。
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来源期刊
BMC Gastroenterology
BMC Gastroenterology 医学-胃肠肝病学
CiteScore
4.20
自引率
0.00%
发文量
465
审稿时长
6 months
期刊介绍: BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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