Core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition disease: OMERACT delphi survey to establish consensus

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-03-07 DOI:10.1016/j.semarthrit.2025.152669

Yiling Zhang , Sara K. Tedeschi , Abhishek Abhishek , Owen Hensey , David Grossberg , Ken Cai , Beverley Shea , Jasvinder A. Singh , Robin Christensen , Teodora Serban , Edoardo Cipolletta , Konstantinos Parperis , Cesar Diaz-Torne , Geraldine M McCarthy , Fabio Becce , Tamer A Gheita , Silvia Sirotti , Sara Nysom Christiansen , Luis Coronel , Lisa K Stamp , Nicola Dalbeth

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引用次数: 0

Abstract

Objective

To agree on important domains for the Outcome Measures in Rheumatology (OMERACT) core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition (CPPD) disease.

Methods

Patient research partners (PRPs) and other participants (mainly clinicians and researchers) contributed to three rounds of a consensus survey using Delphi methodology. Consensus was defined if ≥70% of both patients and other participants scored the domain as ‘critically important domain to include’. In a subsequent ranking exercise, all participants were asked to select and rank up to 10 of the domains reaching consensus.

Results

Fifteen domains reached consensus as critically important. Within the Pathophysiological Manifestations area, these were joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare, joint damage on imaging tests, joint calcification on imaging tests, and crystals in joint fluid. Within the Life Impact area, these were overall function, ability to complete daily tasks, ability to work, health related quality of life, patient global assessment response to treatment, patient global assessment of disease activity, physician global assessment of disease activity, and patient satisfaction with treatment. No domains within the Societal/Resource Use area reached consensus as critically important. In the ranking exercise, joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare and overall function were most highly ranked.

Conclusion

This work has identified potential domains for the OMERACT core domain set for chronic and/or recurrent manifestations of CPPD disease. There was strong support for joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare, overall function, and global assessments of disease activity as core domains.

查看原文本刊更多论文

焦磷酸钙沉积病慢性和/或复发表现的核心领域设置：OMERACT德尔菲调查建立共识

目的：就风湿病预后指标（OMERACT）核心指标慢性和/或复发性焦磷酸钙沉积（CPPD）疾病的重要领域达成一致。方法采用德尔菲法，对患者研究伙伴（PRPs）和其他参与者（主要是临床医生和研究人员）进行三轮共识调查。如果≥70%的患者和其他参与者将该领域评为“至关重要的领域”，则定义共识。在随后的排名练习中，所有参与者被要求选择并排名最多10个达成共识的领域。结果15个领域达成共识，认为至关重要。病理生理表现包括关节疼痛、关节压痛、关节肿胀、急性CPP结晶性关节炎发作、影像学检查显示的关节损伤、影像学检查显示的关节钙化和关节液中的晶体。在生活影响范围内，这些包括整体功能、完成日常任务的能力、工作能力、与健康相关的生活质量、患者对治疗的总体评估、患者对疾病活动的总体评估、医生对疾病活动的总体评估和患者对治疗的满意度。在社会/资源利用领域内，没有任何领域达成至关重要的共识。在排名运动中，关节疼痛、关节压痛、关节肿胀、急性CPP晶体关节炎发作和整体功能排名最高。这项工作已经确定了CPPD慢性和/或复发表现的OMERACT核心结构域集的潜在结构域。关节疼痛、关节压痛、关节肿胀、急性CPP晶体关节炎发作、整体功能和疾病活动的整体评估作为核心领域得到了强有力的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.