Oxytocin receptors within the caudal lateral septum regulate social approach-avoidance, long-term social discrimination, and anxiety-like behaviors in adult male and female rats

IF 4.6 2区 医学 Q1 NEUROSCIENCES
Fardad Pirri , Cheryl M. McCormick
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Abstract

OTR signaling promotes social approach or facilitates social avoidance, depending on the brain region involved. The lateral septum plays a critical role in regulating social interactions and memory. We investigated the role of OTR signaling in the caudodorsal lateral septum (LSc.d) in modulating social approach-avoidance behavior, long-term social discrimination memory, and anxiety-like behaviors in adult rats. Local infusion of the selective OTR antagonist L-368,899 (1 μg/0.5 μl) into the LSc.d decreased social approach, increased social vigilance, and reduced long-term social discrimination memory in both sexes. Administration of the biased OTR/Gq agonist carbetocin (0.5 μg/0.5 μl) reduced social approach and long-term social discrimination memory in both sexes, and had anxiogenic effects (increased latency to consume palatable food in test arena) only in males. In contrast, the full OTR agonist TGOT (50 ng/0.5 μl) had no effect on social approach or long-term social discrimination memory, and decreased latency to consume palatable food (anxiolytic effect). The results indicate that the oxytocin system can both promote and inhibit social behaviors depending on the differential activation of G-protein subunits and β-arrestins, as well as the pivotal role of the LS in modulating social and anxiety-like behavior in rats.
尾侧隔膜内的催产素受体调节成年雄性和雌性大鼠的社交回避、长期社交歧视和焦虑样行为
OTR信号促进社会接近或促进社会回避,这取决于所涉及的大脑区域。侧隔在调节社会互动和记忆方面起着关键作用。我们研究了成年大鼠尾背外侧隔(LSc.d)的OTR信号在调节社会趋近-回避行为、长期社会歧视记忆和焦虑样行为中的作用。选择性OTR拮抗剂L-368,899 (1 μg/0.5 μl)局部注入LSc。D降低了两性的社会接近性,提高了社会警惕性,降低了长期社会歧视记忆。偏置OTR/Gq激动剂卡贝菌素(0.5 μg/0.5 μl)降低了两性的社会接近和长期社会歧视记忆,并仅在男性中产生焦虑效应(增加了在测试场所食用美味食物的潜伏期)。相反,全效OTR激动剂TGOT (50 ng/0.5 μl)对社会接近和长期社会歧视记忆没有影响,并降低了美味食物的进食延迟(焦虑作用)。结果表明,催产素系统通过g蛋白亚基和β-阻滞蛋白的差异激活,促进和抑制大鼠的社交行为,以及LS在调节大鼠社交和焦虑样行为中的关键作用。
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来源期刊
Neuropharmacology
Neuropharmacology 医学-神经科学
CiteScore
10.00
自引率
4.30%
发文量
288
审稿时长
45 days
期刊介绍: Neuropharmacology publishes high quality, original research and review articles within the discipline of neuroscience, especially articles with a neuropharmacological component. However, papers within any area of neuroscience will be considered. The journal does not usually accept clinical research, although preclinical neuropharmacological studies in humans may be considered. The journal only considers submissions in which the chemical structures and compositions of experimental agents are readily available in the literature or disclosed by the authors in the submitted manuscript. Only in exceptional circumstances will natural products be considered, and then only if the preparation is well defined by scientific means. Neuropharmacology publishes articles of any length (original research and reviews).
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