Comparison of ¹⁸F-fluorodeoxyglucose PET and ⁶⁸Ga-fibroblast Activation Protein Inhibitor PET in Head and Neck Cancers: A Systematic Review and Meta-analysis.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Academic Radiology Pub Date : 2025-03-10 DOI:10.1016/j.acra.2025.02.038

Shuhui Huang, Yueqi Wang, Rui Huang

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引用次数: 0

Abstract

Objectives: This study aimed to compare the diagnostic efficiency of ⁶⁸Ga-fibroblast activation protein inhibitor (FAPI) positron emission tomography (PET) and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET in patients with head and neck cancer (HNC).

Data sources: PubMed, Embase, Web of Science, and the Cochrane Library were used to perform a systemic search through June 26, 2024.

Methods: Studies comparing the diagnostic value of ⁶⁸Ga-FAPI PET and ¹⁸F-FDG PET in patients with HNC were included. We performed a bivariate meta-analysis of diagnostic data and a meta-analysis of the quantitative parameters. The summary receiver operating characteristic curve was plotted, and publication bias was evaluated via Egger's test.

Results: The meta-analysis included 12 studies on 386 patients with HNC. ⁶⁸Ga-FAPI PET had superior pooled sensitivity to ¹⁸F-FDG PET in detecting primary/recurrent tumors and distant metastases in both lesion-based analysis and patient-based analysis. Although the sensitivity of ¹⁸F-FDG PET for detecting lymph node metastases was greater than that of ⁶⁸Ga-FAPI PET (0.93 [95% CI 0.83-0.97] vs. 0.82 [95% CI 0.63-0.93]), the specificity of ¹⁸F-FDG PET was lower than that of ⁶⁸Ga-FAPI PET (0.36 [95% CI 0.01-0.96] vs. 0.97 [95% CI 0.53-1.00]). In addition, ⁶⁸Ga-FAPI PET had a higher pooled mean maximum standardized uptake value for distant metastases (3.28 [95% CI 1.90-4.66]) and a higher pooled mean tumor-to-background ratio for primary/recurrent tumors (1.24 [95% CI 0.44-2.04]) than ¹⁸F-FDG PET.

Conclusion: Compared to ¹⁸F-FDG PET, ⁶⁸Ga-FAPI PET has superior diagnostic accuracy in HNC lesions. Thus, ⁶⁸Ga-FAPI PET may be a better tool for staging and restaging than ¹⁸F-FDG PET in patients with HNC.

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.