Vitamin D receptor FokI polymorphism as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patients.

IF 1.8 4区 医学 Q3 GENETICS & HEREDITY
Journal of neurogenetics Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI:10.1080/01677063.2025.2473705
Aurelia Vania, Dewa Putu Gde Purwa Samatra, I Made Oka Adnyana, Made Ratna Saraswati, Agus Eka Darwinata, I Putu Eka Widyadharma
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引用次数: 0

Abstract

Painful diabetic neuropathy (PDN) is a common complication in patients with type 2 diabetes mellitus (T2DM) with disruption of vitamin D (VD) activity as one of the risk factors. Active VD exerts its biological functions through the vitamin D receptor (VDR), which polymorphisms in the VDR gene can impair. This study aims to establish VDR FokI and ApaI polymorphisms as risk factors for PDN. This case-control study used samples from T2DM patients with and without PDN. Neuropathic pain was diagnosed using the DN4 questionnaire, while FokI and ApaI polymorphisms were examined using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method. Other factors examined included gender, hypertension, current insulin use, obesity, HbA1c levels, and dyslipidemia. A total of 64 subjects were involved in the study. The FokI polymorphism (CT+TT genotype) was a significant risk factor for PDN (OR 4.20; 95% CI [1.47-11.94]; p = 0.012). The T allele in the FokI polymorphism significantly increased the risk of PDN by 2.8 times (OR 2.78; 95% CI [1.28-6.01], p = 0.014). The ApaI polymorphism was not significantly associated with PDN. Diabetes duration ≥4.5 years and uncontrolled diabetes were other significant risk factors for PDN. Multivariate analysis identified three significant variables: FokI polymorphism (OR 5.00; 95% CI [1.37-18.24], p = 0.015), insulin use (OR 4.95; 95% CI [1.37-17.87], p = 0.015), and uncontrolled diabetes (OR 3.47; 95% CI [1.03-11.69], p = 0.045). The VDR FokI polymorphism with the T allele is a significant genetic risk factor for PDN in T2DM patients. The VDR ApaI polymorphism was not a significant risk factor for PDN.

维生素D受体FokI多态性是2型糖尿病患者疼痛性糖尿病神经病变的危险因素
疼痛性糖尿病神经病变(PDN)是2型糖尿病(T2DM)患者常见的并发症,维生素D (VD)活性紊乱是其危险因素之一。活性VD通过维生素D受体(VDR)发挥其生物学功能,而VDR基因的多态性会对其造成损害。本研究旨在建立VDR FokI和ApaI多态性作为PDN的危险因素。该病例对照研究使用了伴有和不伴有PDN的T2DM患者的样本。采用DN4问卷诊断神经性疼痛,采用聚合酶链反应-限制性片段长度多态性法检测FokI和ApaI多态性。其他检查的因素包括性别、高血压、当前胰岛素使用、肥胖、糖化血红蛋白水平和血脂异常。共有64名受试者参与了这项研究。FokI多态性(CT+TT基因型)是PDN的重要危险因素(OR 4.20;95% ci [1.47-11.94];p = 0.012)。FokI多态性中的T等位基因使PDN的风险显著增加2.8倍(OR 2.78;95% CI [1.28-6.01], p = 0.014)。ApaI多态性与PDN无显著相关性。糖尿病病程≥4.5年和未控制的糖尿病是PDN的其他重要危险因素。多因素分析发现三个显著变量:FokI多态性(OR 5.00;95% CI [1.37-18.24], p = 0.015),胰岛素使用(OR 4.95;95% CI [1.37-17.87], p = 0.015)和未控制的糖尿病(OR 3.47;95% CI [1.03-11.69], p = 0.045)。带有T等位基因的VDR FokI多态性是T2DM患者PDN的重要遗传危险因素。VDR ApaI多态性不是PDN的重要危险因素。
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来源期刊
Journal of neurogenetics
Journal of neurogenetics 医学-神经科学
CiteScore
4.40
自引率
0.00%
发文量
13
审稿时长
>12 weeks
期刊介绍: The Journal is appropriate for papers on behavioral, biochemical, or cellular aspects of neural function, plasticity, aging or disease. In addition to analyses in the traditional genetic-model organisms, C. elegans, Drosophila, mouse and the zebrafish, the Journal encourages submission of neurogenetic investigations performed in organisms not easily amenable to experimental genetics. Such investigations might, for instance, describe behavioral differences deriving from genetic variation within a species, or report human disease studies that provide exceptional insights into biological mechanisms
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