{"title":"Targeting the Autonomic Nervous System for Treatment of Urinary Incontinence.","authors":"Guillermo Conde-Santos, Barbara Padilla-Fernández","doi":"10.1016/j.euf.2025.02.015","DOIUrl":null,"url":null,"abstract":"<p><p>Urinary incontinence is a difficult condition that affects millions of people around the world. Recent research has opened the door to understanding the involvement of imbalance in the autonomic nervous system (ANS) as a cause of urge urinary incontinence (UUI) and has highlighted the therapeutic potential of targeting the sympathetic and parasympathetic pathways. This mini-review discusses current pharmacological and neuromodulation approaches that act on the ANS to restore bladder function. Future research should investigate the role of the ANS in bladder dysfunction and incontinence in more depth, and assess optimization of neuromodulation protocols and therapy combination to improve outcomes for patients with UUI. PATIENT SUMMARY: Our mini-review discusses dysfunction of the autonomic nervous system (ANS) as a possible cause of urge urinary incontinence. We describe treatments that could have an effect on incontinence by improving the balance of the ANS. Further research is needed to define the role of the ANS in tailoring treatment for individual patients.</p>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":" ","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European urology focus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.euf.2025.02.015","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Urinary incontinence is a difficult condition that affects millions of people around the world. Recent research has opened the door to understanding the involvement of imbalance in the autonomic nervous system (ANS) as a cause of urge urinary incontinence (UUI) and has highlighted the therapeutic potential of targeting the sympathetic and parasympathetic pathways. This mini-review discusses current pharmacological and neuromodulation approaches that act on the ANS to restore bladder function. Future research should investigate the role of the ANS in bladder dysfunction and incontinence in more depth, and assess optimization of neuromodulation protocols and therapy combination to improve outcomes for patients with UUI. PATIENT SUMMARY: Our mini-review discusses dysfunction of the autonomic nervous system (ANS) as a possible cause of urge urinary incontinence. We describe treatments that could have an effect on incontinence by improving the balance of the ANS. Further research is needed to define the role of the ANS in tailoring treatment for individual patients.
期刊介绍：
European Urology Focus is a new sister journal to European Urology and an official publication of the European Association of Urology (EAU).
EU Focus will publish original articles, opinion piece editorials and topical reviews on a wide range of urological issues such as oncology, functional urology, reconstructive urology, laparoscopy, robotic surgery, endourology, female urology, andrology, paediatric urology and sexual medicine. The editorial team welcome basic and translational research articles in the field of urological diseases. Authors may be solicited by the Editor directly. All submitted manuscripts will be peer-reviewed by a panel of experts before being considered for publication.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
