Managing Opioid Tolerance: Balancing Pain Relief and Tackling Addiction.

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Astha Mehta, Anunav Ashish, Shubham Thakur
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引用次数: 0

Abstract

This editorial discusses opioid tolerance, a growing challenge in managing pain in chronic patients. With time, overuse of opioids causes less sensitivity and responsiveness of opioid receptors and leads to higher doses of opioids for the same level of pain management. Due to this, it increases the risk of side effects, such as opioid addiction, respiratory issues, and overdose. The editorial highlights the relationship between opioid use disorder (OUD) and opioid tolerance and discusses the difficulty faced by patients and doctors during opioid tolerance. To address these challenges, a multimodal pain management approach, including physical therapies, cognitive-behavioural therapy, and opioid rotation, is proposed to enhance pain relief while reducing dependency. Policy changes and further research into alternative pain management methods and mechanisms of opioid tolerance in patients are needed to improve and limit the opioid crisis effectively.

管理阿片类药物耐受性:平衡疼痛缓解和解决成瘾。
这篇社论讨论了阿片类药物耐受性,这是管理慢性患者疼痛的一个日益增长的挑战。随着时间的推移,过度使用阿片类药物会导致阿片类受体的敏感性和反应性降低,并导致更高剂量的阿片类药物用于相同水平的疼痛管理。因此,它增加了副作用的风险,如阿片类药物成瘾、呼吸问题和过量服用。这篇社论强调了阿片类药物使用障碍(OUD)与阿片类药物耐受性之间的关系,并讨论了患者和医生在阿片类药物耐受性过程中面临的困难。为了应对这些挑战,提出了一种多模式疼痛管理方法,包括物理治疗、认知行为治疗和阿片类药物轮换,以增强疼痛缓解,同时减少依赖性。需要改变政策,进一步研究替代疼痛管理方法和患者阿片类药物耐受性机制,以有效改善和限制阿片类药物危机。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current drug safety
Current drug safety PHARMACOLOGY & PHARMACY-
CiteScore
2.10
自引率
0.00%
发文量
112
期刊介绍: Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.
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