Omega-3 polyunsaturated fatty acids attenuates cognitive impairment via the gut-brain axis in diabetes-associated cognitive dysfunction rats

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-03-09 DOI:10.1016/j.bbi.2025.03.015

Hongying Huang , Tong Zhao , Weiwei Ma

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Abstract

Diabetes-related cognitive dysfunction (DACD) is a comorbidity of type 2 diabetes that has a negative effect on patients’ quality of life. Research has indicated that disruption of the gut microbiota (GM) may be linked to dementia with altered cognitive performance. Conversely, omega-3 polyunsaturated fatty acids (n-3 PUFAs) may reverse DACD. The present study aimed to assess the effects of an n-3 PUFA intervention and fecal microbiota transplantation (FMT) on high-fat and streptozotocin-induced DACD model rats. In DACD rats, n-3 PUFA treatment restored fasting blood glucose (FBG) levels and cognitive function, increased the expression of anti-inflammatory cytokines and downregulated the expression of proinflammatory cytokines in the cortex and colon. Additionally, the expression of the postsynaptic density protein-95 mRNA and protein varied with n-3 PUFA treatment. Treatment with n-3 PUFAs also increased the expression of tight junction proteins. Beneficial and short-chain fatty acid-producing bacteria were more abundant when rats were exposed to n-3 PUFAs. After FMT from the rats with DACD symptoms that were improved by the n-3 PUFA dietary intervention into another batch of DACD rats, we observed recovery in recipient DACD rats. These results indicated that the alleviation of DACD symptoms by n-3 PUFAs was attributed to gut microbiota remodeling.

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Omega-3多不饱和脂肪酸通过肠-脑轴减轻糖尿病相关认知功能障碍大鼠的认知损伤。

糖尿病相关认知功能障碍（daca）是2型糖尿病的合并症，对患者的生活质量有负面影响。研究表明，肠道微生物群（GM）的破坏可能与认知能力改变的痴呆症有关。相反，omega-3多不饱和脂肪酸（n-3 PUFAs）可能逆转ddad。本研究旨在评估n-3 PUFA干预和粪便微生物群移植（FMT）对高脂肪和链脲佐菌素诱导的ddad模型大鼠的影响。在daca大鼠中，n-3 PUFA处理恢复了空腹血糖水平和认知功能，增加了抗炎细胞因子的表达，下调了皮层和结肠中促炎细胞因子的表达。此外，突触后密度蛋白-95 mRNA和蛋白的表达随n-3 PUFA处理而变化。用n-3 PUFAs处理也增加了紧密连接蛋白的表达。当大鼠暴露于n-3 PUFAs时，有益和短链脂肪酸产生细菌更丰富。将n-3 PUFA饮食干预改善的daca症状大鼠与另一批daca大鼠进行FMT后，我们观察到受体daca大鼠的恢复情况。这些结果表明，n-3 PUFAs减轻daca症状归因于肠道微生物群重塑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.