Endoscopic resection of rectal neuroendocrine tumors: zero disease-related deaths during a 10-year follow-up period.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2025-03-11 DOI:10.1186/s12876-025-03736-y

Yasuyo Hayashi, Haruei Ogino, Yosuke Minoda, Yoshimasa Tanaka, Yoshitaka Hata, Masaru Kubokawa, Seiichiro Sakisaka, Kazuhiro Haraguchi, Shin-Ichiro Fukuda, Soichi Itaba, Daisuke Yoshimura, Shunsuke Takahashi, Munehiro Tanaka, Hiroaki Kubo, Shinichi Somada, Eikichi Ihara, Yoshihiro Ogawa

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引用次数: 0

Abstract

Background: Gastrointestinal neuroendocrine tumors (GI-NETs) are slow-growing tumors with the potential for malignancy that originate from neuroendocrine cells. Therefore, early diagnosis and treatment of GI-NETs are necessary to prevent metastasis. The widespread use of colonoscopy, which allows early detection of rectal neuroendocrine tumors (rNETs) that are small enough to be treated endoscopically, has resulted in an increasing rate of endoscopic resection of rNETs. However, whether the long-term prognosis of endoscopically resected rNETs is favorable has not yet been determined. This study aimed to assess whether endoscopically resected rNETs affect the long-term prognosis of patients.

Methods: We retrospectively reviewed the medical records of 163 consecutive patients with rNETs who underwent endoscopic resection at 11 hospitals in Japan between 1999 and 2012. The primary analysis focused on 47 patients with 51 rNETs who underwent ≥ 10 years of follow-up. The secondary analysis focused on patients who underwent less than 10 years of follow-up.

Results: The median follow-up period of patients included in the primary analysis was 12.3 years (range, 10-19.1 years). The median lesion size was 5 mm (range, 2-12). Three lesions were treated using conventional endoscopic mucosal resection (EMR). Twenty-nine lesions were treated using modified EMR. Nineteen lesions were treated using endoscopic submucosal dissection. The R1 resection rate and lymphovascular invasion rate were 15.7% and 25.5%, respectively. The curative resection (CR) rate and non-CR rate were 66.7% and 33.3%, respectively. Two patients with lesions treated with non-CR underwent radical surgery. None of the 47 patients experienced lesion recurrence during the 10-year follow-up period. Two patients whose lesions were treated with CR died of other diseases.

Conclusions: Death attributable to rNETs did not occur among patients who underwent at least 10 years of follow-up after endoscopic resection.

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内镜下直肠神经内分泌肿瘤切除术：10年随访期间无疾病相关死亡病例。

背景：胃肠道神经内分泌肿瘤（GI-NETs）是一种起源于神经内分泌细胞的生长缓慢且具有恶性肿瘤潜力的肿瘤。因此，早期诊断和治疗GI-NETs是防止转移的必要措施。结肠镜检查的广泛应用，可以早期发现直肠神经内分泌肿瘤（rNETs），这些肿瘤足够小，可以通过内窥镜治疗，这导致了rNETs的内窥镜切除率的增加。然而，内窥镜切除rNETs的长期预后是否良好尚未确定。本研究旨在评估内镜切除的rNETs是否会影响患者的长期预后。方法：我们回顾性回顾了1999年至2012年在日本11家医院连续接受内镜切除的163例rNETs患者的医疗记录。主要分析了47例51例rNETs患者，随访≥10年。二次分析集中在随访时间少于10年的患者。结果：纳入初步分析的患者中位随访期为12.3年（范围10-19.1年）。中位病灶大小为5mm（范围2-12）。三个病变采用常规内镜粘膜切除术（EMR）治疗。29个病灶采用改良EMR治疗。19个病变采用内镜下粘膜下剥离术治疗。R1切除率为15.7%，淋巴血管侵袭率为25.5%。治愈率为66.7%，不治愈率为33.3%。2例病变用非cr治疗的患者行根治性手术。在10年随访期间，47例患者均未出现病变复发。用CR治疗病变的2例患者死于其他疾病。结论：在内镜切除后随访至少10年的患者中，未发生可归因于rNETs的死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.