Effect of 12-wk dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females.

IF 4.1 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Vivian Dos Santos Pinheiro, David N Proctor, Rogerio Nogueira Soares, Thiago Silveira Alvares
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引用次数: 0

Abstract

Menopause is associated with reduced nitric oxide (NO) bioavailability, a key contributor to increased arterial stiffness and, consequently, greater risk of cardiovascular disease-related mortality in postmenopausal females. Even though dietary nitrate has been shown to increase NO bioavailability in postmenopausal females acutely, previous studies showed no impact of dietary nitrate supplementation on arterial stiffness in postmenopausal females. Their findings were likely limited by the acute and/or short-term design. Thus, this study aimed to determine whether 12 wk of dietary nitrate supplementation via beetroot extract improves carotid artery stiffness in postmenopausal females. A randomized, double-blind, placebo-controlled, and parallel-design trial was conducted with 20 postmenopausal females (60-85 yr). Participants received nitrate-rich (NR-BEETx, 8.8 mmol/day) or nitrate-depleted (ND-BEETx) beetroot extract. Carotid stiffness parameters-pulse wave velocity (PWVβ), β stiffness, pressure-strain elastic modulus, augmentation index (AIx), and arterial compliance-were measured at baseline and weeks 4, 8, and 12. Serum nitrate and nitrite concentrations and blood pressure were also assessed. Compared with ND-BEETx, NR-BEETx supplementation significantly reduced PWVβ, β stiffness, elastic modulus, and AIx at weeks 4, 8, and 12, whereas arterial compliance increased by week 12. Serum nitrate and nitrite concentrations were elevated five- to sixfold and 1.5- to 2-fold, respectively, in the NR-BEETx group, with peak concentrations occurring at week 8 and showing a plateau or slight decrease at week 12. Blood pressure remained unchanged in both groups. Twelve weeks of nitrate-rich beetroot extract supplementation improved carotid artery stiffness and increased NO bioavailability without altering blood pressure. These findings suggest that beetroot extract supplementation can be recommended as an alternative nutritional strategy to mitigate carotid artery stiffening in postmenopausal females.NEW & NOTEWORTHY Postmenopausal females experience reduced nitric oxide (NO) bioavailability and elevated carotid artery stiffness, a well-established independent risk factor for end-organ damage and all-cause mortality. In this study, we demonstrate that 12 wk of dietary nitrate supplementation through beetroot extract significantly increased NO bioavailability and improved carotid artery stiffness in postmenopausal females.

12周膳食补充硝酸盐对绝经后女性颈动脉僵硬度的影响。
绝经与一氧化氮(NO)生物利用度降低有关,一氧化氮是导致动脉僵硬增加的关键因素,因此,绝经后女性心血管疾病(CVD)相关死亡风险更高。尽管膳食硝酸盐已被证明能显著提高绝经后女性一氧化氮的生物利用度,但之前的研究显示,膳食硝酸盐补充对绝经后女性动脉僵硬度没有影响。他们的发现可能受到急性和/或短期设计的限制。因此,本研究旨在确定通过甜菜根提取物补充12周的膳食硝酸盐是否能改善绝经后女性的颈动脉僵硬度。对20名绝经后女性(60-85岁)进行了随机、双盲、安慰剂对照、平行设计试验。参与者接受富含硝酸盐(NR-BEETx, 8.8 mmol/day)或硝酸盐消耗(ND-BEETx)的甜菜根提取物。在基线和第4、8和12周测量颈动脉刚度参数-脉冲波速度(PWVβ)、β-刚度、压力-应变弹性模量、增强指数(AIx)和动脉顺应性。血清硝酸盐和亚硝酸盐浓度及血压也被评估。与ND-BEETx相比,在第4、8和12周,补充NR-BEETx显著降低PWVβ、β-刚度、弹性模量和AIx,而动脉顺应性在第12周增加。NR-BEETx组血清硝酸盐和亚硝酸盐浓度分别升高5-6倍和1.5-2倍,浓度在第8周达到峰值,在第12周呈平稳期或略有下降。两组的血压都保持不变。补充12周富含硝酸盐的甜菜根提取物可改善颈动脉僵硬度,增加NO生物利用度,但不会改变血压。这些发现表明,甜菜根提取物补充剂可以推荐作为一种替代营养策略,以减轻绝经后女性颈动脉硬化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.60
自引率
10.40%
发文量
202
审稿时长
2-4 weeks
期刊介绍: The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. The journal embraces new descriptions of these functions and their control systems, as well as their basis in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new mechanistic physiological insights that determine the performance of the normal and abnormal heart and circulation.
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