Immigrant status and citizenship relationships with epigenetic aging in a representative sample of United States adults.

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI:10.1080/17501911.2025.2476378

Jamaji C Nwanaji-Enwerem, Patricia Rodriguez Espinosa, Dennis Khodasevich, Nicole Gladish, Hanyang Shen, Anne K Bozack, Saher Daredia, Belinda L Needham, David H Rehkopf, Andres Cardenas

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引用次数: 0

Abstract

Background: Immigrant status and citizenship influence health and well-being, yet their associations with DNA methylation (DNAm)-based biomarkers of aging - key predictors of healthspan and lifespan, also known as epigenetic aging - remain underexplored.

Methods: Using a representative sample of 2,336 United States (U.S.) adults from the 1999-2000 and 2001-2002 cycles of the National Health and Nutrition Examination Survey (NHANES), we analyzed cross-sectional associations of immigrant status and U.S. citizenship with seven epigenetic aging biomarkers: HannumAge, HorvathAge, SkinBloodAge, PhenoAge, GrimAge2, DNAm Telomere Length, and DunedinPoAm.

Results: After adjusting for demographic factors, immigrants had 2.53-year lower GrimAge2 measures (95%CI: -3.44, -1.63, p < 0.001) compared to non-immigrants. U.S. citizens had 1.98-year higher GrimAge2 measures (95%CI: 0.66, 3.30, p = 0.005) compared to non-citizens. The GrimAge2 associations with immigrant status (β = -1.04-years, 95%CI: -1.87, -0.21, p = 0.02) and citizenship (β = 1.35-years, 95%CI: 0.38, 2.32, p = 0.02) were attenuated after adjusting for other lifestyle/health variables. Immigrant status and citizenship were associated with estimated levels of several GrimAge2 DNAm component proteins, including adrenomedullin and C-reactive protein.

Conclusion: Our results support the paradigm of the immigrant mortality advantage and highlight the potential value of epigenetic age measures in studying socioeconomic and broader factors influencing citizen and immigrant health.

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美国成年人代表性样本中的移民身份和公民身份与表观遗传衰老的关系。

背景：移民身份和公民身份影响健康和福祉，但它们与基于DNA甲基化（DNAm）的衰老生物标志物（健康寿命和寿命的关键预测因素，也称为表观遗传衰老）的关联仍未得到充分探讨。方法：使用1999-2000年和2001-2002年国家健康与营养调查（NHANES）周期的2336名美国成年人的代表性样本，我们分析了移民身份和美国公民身份与7个表观遗传衰老生物标志物的横断面关联：HannumAge， HorvathAge, SkinBloodAge, PhenoAge, GrimAge2， DNAm端粒长度和DunedinPoAm。结果：在调整人口因素后，移民的grimag2测量值比非公民低2.53年（95%CI: -3.44, -1.63, p = 0.005）。调整其他生活方式/健康变量后，GrimAge2与移民身份（β = -1.04年，95%CI: -1.87, -0.21, p = 0.02）和公民身份（β = 1.35年，95%CI: 0.38, 2.32, p = 0.02）的相关性减弱。移民身份和公民身份与几种GrimAge2 DNAm成分蛋白的估计水平有关，包括肾上腺髓质素和c反应蛋白。结论：我们的研究结果支持移民死亡率优势的范式，并突出了表观遗传年龄测量在研究影响公民和移民健康的社会经济和更广泛因素方面的潜在价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.