Parental fracture history is associated with offspring early-life fracture risk: The Geelong Osteoporosis Study

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Bone Pub Date : 2025-03-08 DOI:10.1016/j.bone.2025.117454

Mia A. Percival , Kara B. Anderson , Julie A. Pasco , Sarah M. Hosking , Natalie K. Hyde

{"title":"Parental fracture history is associated with offspring early-life fracture risk: The Geelong Osteoporosis Study","authors":"Mia A. Percival , Kara B. Anderson , Julie A. Pasco , Sarah M. Hosking , Natalie K. Hyde","doi":"10.1016/j.bone.2025.117454","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>Fractures during childhood and adolescence are common as peak bone mass has not yet been accrued. Previous studies have reported that offspring are at higher risk of a fragility fracture if one or both parents have experienced a fracture, however, it is not known if this association holds true for fractures experienced in early life, and if so, whether there are differential risk profiles across the sexes. Therefore, this study aimed to determine the associations between maternal and paternal fracture history and offspring fracture risk in early life.</div></div><div><h3>Methods</h3><div>At baseline, Geelong Osteoporosis Study participants self-reported fracture history for themselves and their parents. This analysis included personal fracture data relating to birth until 20 years of age and parental fracture for 1336 female and 1174 male participants who provided complete data, including age and site of fracture. Multivariable logistic regression models were used to assess the odds of participant fracture in childhood or adolescence in association with paternal and/or maternal fracture.</div></div><div><h3>Results</h3><div>In total, 141 (12.2 %) female and 323 (25.7 %) male participants reported at least one fracture by age 20 years. For females, there were 247 maternal and 211 paternal parents with fractures and in males, 233 maternal and 189 paternal fractures. A maternal fracture was associated with an increased odds of early life fracture in female participants (OR 1.86; 95 % CI 1.17–2.95) but not male participants (OR 1.16; 95 % CI 0.81–1.65), while a paternal fracture was associated with an increased odds of early life fracture in males (OR 1.47; 95 % CI 1.01–2.14) but not females (OR 1.61; 95 % CI 0.98–2.64).</div></div><div><h3>Conclusion</h3><div>Parental fracture history appears to have sex-specific associations with offspring early life fracture risk. Whereby maternal fracture history is associated with an increased risk of early life fracture in females, while paternal fracture history is associated with early life fracture risk in males.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117454"},"PeriodicalIF":3.5000,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bone","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S8756328225000663","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aims

Fractures during childhood and adolescence are common as peak bone mass has not yet been accrued. Previous studies have reported that offspring are at higher risk of a fragility fracture if one or both parents have experienced a fracture, however, it is not known if this association holds true for fractures experienced in early life, and if so, whether there are differential risk profiles across the sexes. Therefore, this study aimed to determine the associations between maternal and paternal fracture history and offspring fracture risk in early life.

Methods

At baseline, Geelong Osteoporosis Study participants self-reported fracture history for themselves and their parents. This analysis included personal fracture data relating to birth until 20 years of age and parental fracture for 1336 female and 1174 male participants who provided complete data, including age and site of fracture. Multivariable logistic regression models were used to assess the odds of participant fracture in childhood or adolescence in association with paternal and/or maternal fracture.

Results

In total, 141 (12.2 %) female and 323 (25.7 %) male participants reported at least one fracture by age 20 years. For females, there were 247 maternal and 211 paternal parents with fractures and in males, 233 maternal and 189 paternal fractures. A maternal fracture was associated with an increased odds of early life fracture in female participants (OR 1.86; 95 % CI 1.17–2.95) but not male participants (OR 1.16; 95 % CI 0.81–1.65), while a paternal fracture was associated with an increased odds of early life fracture in males (OR 1.47; 95 % CI 1.01–2.14) but not females (OR 1.61; 95 % CI 0.98–2.64).

Conclusion

Parental fracture history appears to have sex-specific associations with offspring early life fracture risk. Whereby maternal fracture history is associated with an increased risk of early life fracture in females, while paternal fracture history is associated with early life fracture risk in males.

查看原文本刊更多论文

吉隆骨质疏松症研究：父母骨折史与后代早期骨折风险相关

目的：骨折在儿童和青少年时期是常见的，因为峰值骨量尚未积累。先前的研究报道，如果父母一方或双方都经历过骨折，那么后代患脆性骨折的风险更高，然而，尚不清楚这种关联是否适用于早期经历的骨折，如果是这样，是否存在性别差异的风险特征。因此，本研究旨在确定母亲和父亲的骨折史与后代早期骨折风险之间的关系。方法：在基线时，吉隆骨质疏松研究参与者自我报告自己和父母的骨折史。该分析包括1336名女性和1174名男性参与者的出生至20 岁的个人骨折数据和父母骨折数据，这些参与者提供了完整的数据，包括年龄和骨折部位。使用多变量logistic回归模型来评估参与者在儿童期或青春期骨折与父亲和/或母亲骨折的关系。结果：总共有141名（12.2 %）女性和323名（25.7 %）男性参与者报告在20 岁时至少发生过一次骨折。女性有247例母亲骨折，211例父亲骨折；男性有233例母亲骨折，189例父亲骨折。母亲骨折与女性参与者早期骨折的几率增加相关(OR 1.86；95 % CI 1.17-2.95)，但没有男性参与者(OR 1.16；95 % CI 0.81-1.65)，而父亲骨折与男性早期骨折的几率增加有关(OR 1.47；95 % CI 1.01-2.14)，但女性没有(OR 1.61；95 % ci 0.98-2.64)。结论：父母骨折史似乎与后代早期骨折风险存在性别特异性关联。因此，母亲骨折史与女性早期骨折风险增加有关，而父亲骨折史与男性早期骨折风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bone 医学-内分泌学与代谢

CiteScore

8.90

自引率

4.90%

发文量

264

审稿时长

30 days

期刊介绍： BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.