Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Inflammatory Bowel Diseases Pub Date : 2025-09-01 DOI:10.1093/ibd/izaf045

Muktesh Mohan, Oana-Maria Thoma, Shivani Sharma, Gargi Sharma, Markus F Neurath, Maximillian Waldner, Kanwarpal Singh

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Abstract

Background: Inflammatory bowel disease (IBD) is one of the fastest-growing diseases globally. Nearly 5 million people are affected by IBD, with an incremental growth rate of 47.45% between 1990 and 2019.

Aim and methods: We aim to provide a noninvasive approach to detecting IBD with an in-house developed 1310 nm endoscopic optical coherence tomography (OCT) system. Mice with acute colitis underwent a longitudinal colon imaging process for real-time and long-run disease progression. The OCT images were processed and segmented using a computer vision image processing-based segmentation algorithm for further thickness mapping and attenuation coefficient calculations.

Result: An increase in overall colon wall thickness due to inflammation was observed, as well as a reduction in attenuation coefficient due to a change in refractive index.

Conclusion: Comparable results with white light endoscope and histological examination suggest the clinical potential of the 1310 nm endoscopic OCT system for in vivo assessment of IBD.

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利用内窥镜光学相干断层扫描纵向监测小鼠炎症性肠病。

背景：炎症性肠病（IBD）是全球增长最快的疾病之一。近500万人受到IBD的影响，1990年至2019年期间的增量增长率为47.45%。目的和方法：我们的目标是利用内部开发的1310 nm内窥镜光学相干断层扫描（OCT）系统提供一种无创检测IBD的方法。急性结肠炎小鼠进行了实时和长期疾病进展的纵向结肠成像过程。使用基于计算机视觉图像处理的分割算法对OCT图像进行处理和分割，进一步进行厚度映射和衰减系数计算。结果：观察到炎症导致整体结肠壁厚度增加，同时由于折射率变化导致衰减系数降低。结论：与白光内窥镜和组织学检查比较的结果表明，1310 nm内窥镜OCT系统在体内评估IBD的临床潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammatory Bowel Diseases 医学-胃肠肝病学

CiteScore

9.70

自引率

6.10%

发文量

462

审稿时长

1 months

期刊介绍： Inflammatory Bowel Diseases® supports the mission of the Crohn''s & Colitis Foundation by bringing the most impactful and cutting edge clinical topics and research findings related to inflammatory bowel diseases to clinicians and researchers working in IBD and related fields. The Journal is committed to publishing on innovative topics that influence the future of clinical care, treatment, and research.