BODIPY-Based Small-Molecule Photoacoustic Probes for Biomedical Imaging

IF 3 4区化学 Q3 CHEMISTRY, PHYSICAL

ChemPhotoChem Pub Date : 2024-12-17 DOI:10.1002/cptc.202400335

Kaixuan Song, Hu Gao, Xiaoqing Wang, Zhipeng Liu

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Abstract

Advances in bioimaging technologies capable of visualizing physiological and pathological processes are of great significance for revealing diseases development and promoting clinical diagnosis and treatment. Photoacoustic (PA) imaging, utilizing small-molecule probes, offers a promising approach for achieving high-spatiotemporal-imaging of dynamic biological process. The development of near-infrared absorbing dyes has significantly contributed to the research of small-molecule PA probes, particularly boron-dipyrromethene derivatives (BODIPYs) known for their simple synthesis, tunable NIR photophysical properties and superior PA imaging abilities. This review highlights recent advances in biomedical applications of BODIPY-based PA probes, including the design strategies, spectral characteristics, response mechanisms and applications for imaging biomarkers such as reactive oxygen/nitrogen species, gaseous signaling molecules and metal ions. Moreover, their challenges and future prospects are elucidated. The insights provided in this review are expected to guide future studies on small-molecule PA probes for bioimaging and biosensing.

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基于bodipi的生物医学成像小分子光声探针

生物成像技术的发展对揭示疾病的发展，促进临床诊断和治疗具有重要意义。利用小分子探针的光声成像（PA）为实现动态生物过程的高时空成像提供了一种有前途的方法。近红外吸收染料的发展极大地促进了小分子PA探针的研究，特别是硼-二吡咯烷衍生物（BODIPYs）以其简单的合成、可调的近红外光物理性质和优越的PA成像能力而闻名。本文综述了近年来基于bodipi的PA探针在生物医学领域的应用进展，包括设计策略、光谱特性、响应机制以及在活性氧/氮、气体信号分子和金属离子等生物标志物成像中的应用。并对其面临的挑战和未来前景进行了阐述。本综述提供的见解有望指导未来用于生物成像和生物传感的小分子PA探针的研究。

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来源期刊

ChemPhotoChem Chemistry-Physical and Theoretical Chemistry

CiteScore

5.80

自引率

5.40%

发文量

165

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