BODIPY-Based Small-Molecule Photoacoustic Probes for Biomedical Imaging

IF 3 4区 化学 Q3 CHEMISTRY, PHYSICAL
Kaixuan Song, Hu Gao, Xiaoqing Wang, Zhipeng Liu
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引用次数: 0

Abstract

Advances in bioimaging technologies capable of visualizing physiological and pathological processes are of great significance for revealing diseases development and promoting clinical diagnosis and treatment. Photoacoustic (PA) imaging, utilizing small-molecule probes, offers a promising approach for achieving high-spatiotemporal-imaging of dynamic biological process. The development of near-infrared absorbing dyes has significantly contributed to the research of small-molecule PA probes, particularly boron-dipyrromethene derivatives (BODIPYs) known for their simple synthesis, tunable NIR photophysical properties and superior PA imaging abilities. This review highlights recent advances in biomedical applications of BODIPY-based PA probes, including the design strategies, spectral characteristics, response mechanisms and applications for imaging biomarkers such as reactive oxygen/nitrogen species, gaseous signaling molecules and metal ions. Moreover, their challenges and future prospects are elucidated. The insights provided in this review are expected to guide future studies on small-molecule PA probes for bioimaging and biosensing.

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来源期刊
ChemPhotoChem
ChemPhotoChem Chemistry-Physical and Theoretical Chemistry
CiteScore
5.80
自引率
5.40%
发文量
165
期刊介绍: Light plays a crucial role in natural processes and leads to exciting phenomena in molecules and materials. ChemPhotoChem welcomes exceptional international research in the entire scope of pure and applied photochemistry, photobiology, and photophysics. Our thorough editorial practices aid us in publishing authoritative research fast. We support the photochemistry community to be a leading light in science. We understand the huge pressures the scientific community is facing every day and we want to support you. Chemistry Europe is an association of 16 chemical societies from 15 European countries. Run by chemists, for chemists—we evaluate, publish, disseminate, and amplify the scientific excellence of chemistry researchers from around the globe.
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