Carbamazepine-induced severe systemic hypersensitivity reaction with eosinophilia.

M J Robbie, J P Scurry, P Stevenson
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引用次数: 17

Abstract

Skin rash, fever, and eosinophilia developed in a previously healthy 35-year-old woman three weeks after starting carbamazepine. Fulminant respiratory and renal failure ensued. Autopsy showed pneumonitis, nephritis, serositis, pancreatitis, hepatitis, and carditis, characterized by an infiltrate of eosinophils and lymphocytes. The severity, duration, and extensive organ involvement of the reaction make this case unique.

卡马西平诱导的严重全身超敏反应伴嗜酸性粒细胞增多。
一名先前健康的35岁妇女在使用卡马西平三周后出现皮疹、发热和嗜酸性粒细胞增多。随后出现暴发性呼吸衰竭和肾衰竭。尸检显示肺炎、肾炎、浆液炎、胰腺炎、肝炎和心脏炎,以嗜酸性粒细胞和淋巴细胞浸润为特征。这种反应的严重程度、持续时间和广泛的器官受累使本病例独一无二。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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