The association of cervical and lumbar mobility with functional ability in axial spondyloarthritis: Insights from the CASTRO registry using Inertial Measurement Unit system

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-03-03 DOI:10.1016/j.semarthrit.2025.152703

Diana Maria Margareta Moldovan , I. Concepción Aranda-Valera , Lourdes Ladehesa-Pineda , María Carmen Ábalos-Aguilera , María Ángeles Puche-Larrubia , Alejandro Escudero-Contreras , Cristina González-Navas , Juan Luis Garrido-Castro , Daniela Fodor , Eduardo Collantes-Estévez , Clementina López-Medina

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Abstract

Objective

This study aimed to evaluate the association of cervical and lumbar mobility with functional ability in patients with axial spondyloarthritis (axSpA) using an inertial measurement unit (IMU) sensor system, as well as the influence of disease duration on this association.

Methods

This cross-sectional study included 156 patients with axSpA from the Córdoba axSpA Task Force Registry and Outcomes (CASTRO) registry. Spinal mobility was assessed with the IMU system and functional ability was measured using the Bath Ankylosing Spondylitis Functional Index (BASFI). Patients were categorized into non-longstanding (≤23 years) and longstanding (>23 years) groups based on the median disease duration. Univariable and multivariable linear regressions were conducted to evaluate the variability of BASFI explained by each spinal movement (coefficient of determination [R²]).

Results

Multivariable linear regression analysis showed that cervical movements collectively explained 19.9 % (R² = 0.199) of BASFI variability, while lumbar mobility accounted for 11.3 %. Among longstanding axSpA patients, cervical rotation (unstandardized regression coefficient [B] = -0.68, 95 % CI1.13 to -0.24) and lumbar flexion (B = 0.65, 95 % CI 0.05 to 1.24), were independently associated with the BASFI scores. In non-longstanding patients, lumbar mobility, particularly lumbar rotation (B = -0.51, 95 % CI0.97 to -0.05), showed a stronger association with functional ability.

Conclusions

This study suggests that cervical mobility is more strongly associated with functional ability than lumbar mobility in axSpA patients. However, the impact of cervical and lumbar mobility on functional ability varies with disease duration.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.