Synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-03-06 DOI:10.1016/j.ica.2025.122627

Okan Ucar , Ibrahim I. Ozturk , Anita M. Grześkiewicz , Maciej Kubicki , Christina Banti , Sotiris K. Hadjikakou

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Abstract

The synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr₂(κ²-N³,S-Hatetsc)]} (1) and {[SbCl₂(η¹-S-Hatmtsc)(κ²-N³,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.

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新型不寻常几何形状的锑（III）硫代氨基脲配合物的合成、结构表征和生物学评价

本文报道了含噻吩衍生配体的新型锑（III）硫代氨基脲配合物的合成、结构表征和生物学评价。合成了两个配合物：{[SbBr₂（κ2-N3,S-Hatetsc）]}(1)和{[SbCl₂（η1-S-Hatmtsc）（κ2-N3,S-Hatmtsc）]}(2)。x射线晶体学显示配合物1为畸变跷跷板结构，配合物2为畸变方锥体结构。两种复合物对HeLa癌细胞均表现出明显的抗增殖活性。它们还表现出对革兰氏阴性菌，特别是大肠杆菌的增强抗菌活性。这项研究强调了噻吩基锑（III）配合物作为抗癌和抗菌治疗的有希望的候选者的潜力。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.