A cohort study of ultrasonic semi-quantitative scoring for the diagnosis of serology-negative rheumatoid arthritis.

IF 1.1 Q4 RHEUMATOLOGY
Archives of rheumatology Pub Date : 2024-12-12 eCollection Date: 2024-12-01 DOI:10.46497/ArchRheumatol.2024.10788
Jing Xu, Yiran Gong, Kaiyi Yang, Yabin Fang, Wenting Li, Shuqiang Chen
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Abstract

Objectives: This study aims to explore the value of ultrasonic semi-quantitative scoring in the diagnosis of seronegative rheumatoid arthritis (RA).

Patients and methods: Between January 2018 and October 2023, a total of 411 patients (241 males, 170 females; mean age: 50.9±17.5 years; range, 18 to 87 years) were included. Of these patients, 296 were diagnosed with RA (including 131 with seronegative RA [SNRA] and 165 with seropositive RA [SPRA]) and 115 with non-RA disease. Ultrasound examination was performed on all patients with suspected RA, focusing on evaluation of synovial hypertrophy (SH), power Doppler (PD) signals, and bone erosion (BE) for three to six months. The ultrasonic joint semi-quantitative score was evaluated for the sensitivity and specificity of detecting seronegative RA.

Results: The three indexes of SH, PD, and BE were not significantly different between the SNRA and SPRA groups (p=0.223, p=0.176; p=0.272, respectively). However, there were differences on the SH1, SH3, PD, and BE grades between the SNRA group and the non-RA group (p<0.001 for all); when serology was negative and when the highest scored joint met PD Grade ≥2 or BE Grade ≥2, it showed both high sensitivity (93.12%) and high specificity (91.30%) for the diagnosis of RA.

Conclusion: Ultrasound combined with semi-quantitative scoring is of promising significance in the early diagnosis of SNRA patients.

超声半定量评分诊断血清学阴性类风湿关节炎的队列研究。
目的:探讨超声半定量评分在血清阴性类风湿性关节炎(RA)诊断中的价值。患者与方法:2018年1月至2023年10月,共411例患者(男性241例,女性170例;平均年龄:50.9±17.5岁;年龄范围为18至87岁)。在这些患者中,296例被诊断为RA(其中血清阴性RA 131例,血清阳性RA 165例,SPRA), 115例非RA疾病。所有疑似RA的患者均行超声检查,重点评估滑膜肥大(SH)、功率多普勒(PD)信号和骨侵蚀(BE),检查时间为3 ~ 6个月。评价超声关节半定量评分检测血清阴性RA的敏感性和特异性。结果:SNRA组与SPRA组间SH、PD、BE三项指标比较,差异均无统计学意义(p=0.223, p=0.176;分别为p = 0.272)。但SNRA组与非ra组在SH1、SH3、PD、BE评分上存在差异(p结论:超声联合半定量评分对SNRA患者的早期诊断有很好的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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