Hanieh Taheri, Yang Li, Kevin M Huang, Eman Ahmed, Yan Jin, Thomas Drabison, Yan Yang, Samuel K Kulp, Nicholas A Young, Junan Li, Xiaolin Cheng, Kara N Corps, Christopher C Coss, Jennifer E Vaughn, Maryam B Lustberg, Alex Sparreboom, Shuiying Hu
{"title":"OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor-Associated Arthralgia Susceptibility.","authors":"Hanieh Taheri, Yang Li, Kevin M Huang, Eman Ahmed, Yan Jin, Thomas Drabison, Yan Yang, Samuel K Kulp, Nicholas A Young, Junan Li, Xiaolin Cheng, Kara N Corps, Christopher C Coss, Jennifer E Vaughn, Maryam B Lustberg, Alex Sparreboom, Shuiying Hu","doi":"10.1158/2767-9764.CRC-24-0475","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>AIs are effective but often discontinued because of arthralgia. This study explores the role of OATP1B transporters in AI-related side effects and the potential usage of transporter biomarkers to predict and reduce the risk of arthralgia associated with AI treatment.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"496-510"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948302/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0475","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Significance: AIs are effective but often discontinued because of arthralgia. This study explores the role of OATP1B transporters in AI-related side effects and the potential usage of transporter biomarkers to predict and reduce the risk of arthralgia associated with AI treatment.
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