Toward universal models for collective interactions in biomolecular condensates.

IF 2.9 Q2 BIOPHYSICS
Biophysics reviews Pub Date : 2025-03-07 eCollection Date: 2025-03-01 DOI:10.1063/5.0244227
Edoardo Milanetti, Karan K H Manjunatha, GianCarlo Ruocco, Amos Maritan, Monika Fuxreiter
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引用次数: 0

Abstract

A wide range of higher-order structures, including dense, liquid-like assemblies, serve as key components of cellular matter. The molecular language of how protein sequences encode the formation and biophysical properties of biomolecular condensates, however, is not completely understood. Recent notion on the scale invariance of the cluster sizes below the critical concentration for phase separation suggests a universal mechanism, which can operate from oligomers to non-stoichiometric assemblies. Here, we propose a model for collective interactions in condensates, based on context-dependent variable interactions. We provide the mathematical formalism, which is capable of describing growing dynamic clusters as well as changes in their material properties. Furthermore, we discuss the consequences of the model to maximize sensitivity to the environmental signals and to increase correlation lengths.

迈向生物分子凝聚体集体相互作用的通用模型。
范围广泛的高阶结构,包括密集的、液体状的组合,是细胞物质的关键组成部分。然而,蛋白质序列如何编码生物分子凝聚物的形成和生物物理特性的分子语言尚未完全理解。最近关于低于相分离临界浓度的簇大小的尺度不变性的概念提出了一种普遍的机制,可以从低聚物到非化学计量组合。在这里,我们提出了一个基于环境变量相互作用的凝析油集体相互作用模型。我们提供了数学形式,它能够描述生长的动态簇以及它们的材料性质的变化。此外,我们讨论了模型的结果,以最大限度地提高对环境信号的敏感性和增加相关长度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
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0.00%
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