[Transthyretin Amyloid Cardiomyopathy as the Cause of Aortic Stenosis].

IF 0.5 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
M V Ezhikova, S N Nasonova, I V Zhirov, A A Shoshina, O Ya Tchaikovskaya, S V Dobrovolskaya, A A Ansheles, M A Saidova, S N Tereshchenko
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引用次数: 0

Abstract

Currently, the diagnosis of amyloid cardiomyopathy (ACM) causes great difficulties both for practicing primary care physicians and specialists. One of the reasons is the variety of symptoms in patients with ACM. The most common ACM manifestations include heart failure with preserved left ventricular ejection fraction, hypertrophic phenotype of cardiomyopathy, thromboembolic complications, and valvular apparatus damage. Common valvular manifestations are mitral and tricuspid valve insufficiency and aortic stenosis (AS). Diagnosis is particularly difficult in patients with AS requiring differentiation between AS as a degenerative defect and AS of amyloid origin. According to the literature, in 4-16% of cases of older patients (≥65 years), the genesis of AS is precisely the amyloid damage.

转甲状腺素淀粉样蛋白心肌病是主动脉瓣狭窄的病因。
目前,淀粉样蛋白心肌病(ACM)的诊断给初级保健医生和专科医生带来了很大的困难。原因之一是ACM患者的症状多种多样。最常见的ACM表现包括保留左心室射血分数的心力衰竭、肥厚型心肌病、血栓栓塞并发症和瓣膜损伤。常见的瓣膜表现为二尖瓣和三尖瓣不全和主动脉瓣狭窄。对于需要区分退行性病变和淀粉样蛋白源性病变的AS患者,诊断尤其困难。根据文献,在4-16%的老年患者(≥65岁)中,AS的发生正是淀粉样蛋白损伤。
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来源期刊
Kardiologiya
Kardiologiya 医学-心血管系统
CiteScore
1.70
自引率
20.00%
发文量
94
审稿时长
3-8 weeks
期刊介绍: “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.
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