Effects of exercise in primary Sjögren's syndrome: a systematic review and meta-analysis of randomized clinical trials.

IF 2.1 4区医学 Q1 REHABILITATION

Disability and Rehabilitation Pub Date : 2025-03-10 DOI:10.1080/09638288.2025.2474085

Nazli Elif Nacar, Sezen Karaborklu Argut, Edibe Unal

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引用次数: 0

Abstract

Purpose: To systematically review the effects of exercise interventions on pain, fatigue, quality of life, disease activity, aerobic capacity, and dryness in primary Sjögren's syndrome (pSS), and to determine the most effective type of exercise.

Materials and methods: A literature search was conducted using Web of Science, PubMed/MEDLINE, ProQuest, SCOPUS, Cochrane Library, and PEDro databases. Randomized clinical trials (RCTs) examining the effects of exercise interventions in patients with pSS were included. Methodological quality was assessed using the Risk of Bias version-2 tool and PEDro scale.

Results: Five RCTs, including 269 female patients with pSS were analyzed. High-quality studies indicated that exercise interventions significantly improved pain (p = 0.008), fatigue (p < 0.00001), quality of life (p = 0.0003), and aerobic capacity (p = 0.009) compared to controls. Sensitivity analysis indicated that resistance exercise was particularly effective, significantly improving pain (p < 0.00001), fatigue (p < 0.00001), quality of life (p < 0.00001), and disease activity (p = 0.02).

Conclusion: Exercise interventions may offer significant benefits in reducing pain and fatigue, as well as improving quality of life and aerobic capacity, in patients with pSS compared to no-treatment. Resistance exercise appears to be more effective than other exercise models.

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来源期刊

Disability and Rehabilitation 医学-康复医学

CiteScore

5.00

自引率

9.10%

发文量

415

审稿时长

3-6 weeks

期刊介绍： Disability and Rehabilitation along with Disability and Rehabilitation: Assistive Technology are international multidisciplinary journals which seek to encourage a better understanding of all aspects of disability and to promote rehabilitation science, practice and policy aspects of the rehabilitation process.