The effects of GIP, GLP-1 and GLP-2 on markers of bone turnover: a review of the gut-bone axis.

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Endocrinology Pub Date : 2025-03-26 Print Date: 2025-05-01 DOI:10.1530/JOE-24-0231

Miriam Longo, David S Mathiesen, Lærke S Gasbjerg, Katherine Esposito, Asger B Lund, Filip K Knop

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Abstract

Bone is a dynamic tissue continuously undergoing remodeling processes of resorption and formation to maintain bone mass and health. Food intake and the release of the gut-derived incretin hormones, including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) and its 'sister hormone' glucagon-like peptide 2 (GLP-2), appear to regulate bone turnover processes in the postprandial state as part of the so-called gut-bone axis. The effects of these gut hormones on bone metabolism depend on their circulating concentrations. While at physiological concentrations, elicited by nutrient intake, GIP seems to be the main contributor to postprandial bone resorption; supraphysiological concentrations of gut hormones induce more potent and robust antiresorptive effects. This review provides an overview of the literature describing the role of gut-derived hormones in the regulation and maintenance of bone tissue. In addition, we describe the effects of gut hormone-based treatment modalities on bone health and discuss the potential of gut hormone-based strategies for the treatment of bone disorders in the future.

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GIP、GLP-1和GLP-2对骨转换标志物的影响：肠-骨轴研究综述

骨是一个动态组织，不断经历吸收和形成的重塑过程，以维持骨量和健康。食物摄入和肠源性肠促胰岛素激素的释放，包括葡萄糖依赖性胰岛素性多肽（GIP）和胰高血糖素样肽1 （GLP-1）及其“姐妹激素”胰高血糖素样肽2 (GLP-2)，似乎调节餐后状态下的骨转换过程，作为所谓的肠-骨轴的一部分。这些肠道激素对骨代谢的影响取决于它们的循环浓度。而在生理浓度下，由营养摄入引起，GIP似乎是餐后骨吸收的主要贡献者，超生理浓度的肠道激素诱导更有效和强大的抗骨吸收作用。本文综述了有关肠源性激素在骨组织调节和维持中的作用的文献。此外，我们描述了肠道激素为基础的治疗方式对骨骼健康的影响，并讨论了肠道激素为基础的策略在未来治疗骨骼疾病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.50%

发文量

113

审稿时长

4-8 weeks

期刊介绍： Journal of Endocrinology is a leading global journal that publishes original research articles, reviews and science guidelines. Its focus is on endocrine physiology and metabolism, including hormone secretion; hormone action; biological effects. The journal publishes basic and translational studies at the organ, tissue and whole organism level.