Outcomes of Segmentectomy With or Without Preoperative Biopsy in Non-Small Cell Lung Cancer (NSCLC).

IF 3.3 3区 医学 Q2 ONCOLOGY
Sneha S Alaparthi, Annie Ho, Hamza Rshaidat, Gregory Whitehorn, Isheeta Madeka, Anurag Ishwar, Tyler Grenda, John D Jacob, Nathaniel R Evans, Olugbenga T Okusanya
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引用次数: 0

Abstract

Background: There is a discussion amongst oncologic societies regarding the necessity of preoperative biopsy prior to resection in lung cancer. We aim to examine outcomes of segmentectomy with or without preoperative biopsy in non-small cell lung cancer (NSCLC) patients.

Methods: A retrospective cohort study was conducted utilizing the National Cancer Database. Adult patients diagnosed with clinical stage I (N0 M0, tumor size ≤ 2 cm) NSCLC between 2010 and 2019 who underwent segmentectomy were included. Patients with carcinoid tumors or who received neoadjuvant systemic or radiation therapy were excluded. Demographic and clinical variables were analyzed. Propensity score matching (PSM) was performed to adjust for confounders between patients who underwent segmentectomy with versus without preoperative biopsy. Short term outcomes (readmission, 30-day and 90-day survival) and long-term overall survival (OS) were compared between groups.

Results: In total, 6891 patients met inclusion criteria, of which 2287 (33.2%) underwent preoperative biopsy and 4604 (66.8%) did not. There was no significant difference in 30-day readmission (P = .13), 30-day survival (P = .26), and 90-day survival (P = .31). Patients who did not receive preoperative biopsy was associated with a higher 5-year OS (P = .02); however, post-PSM, there was no significant difference between the 2 groups (P = .20).

Conclusions: After PSM, no significant difference was found in margin positivity, nodal upstaging, 30-day readmission, 30- and 90-day survival, and 5-year OS between cohorts. This demonstrates that segmentectomy without preoperative biopsy remains a safe option for those with early stage, ≤ 2 cm NSCLC.

非小细胞肺癌(NSCLC)的节段切除与术前活检的结果。
背景:肿瘤学会对肺癌切除术前术前活检的必要性进行了讨论。我们的目的是研究非小细胞肺癌(NSCLC)患者进行节段切除和术前活检的结果。方法:利用国家癌症数据库进行回顾性队列研究。纳入2010年至2019年间诊断为临床I期(N0 M0,肿瘤大小≤2 cm)非小细胞肺癌且行节段切除术的成年患者。排除了类癌肿瘤患者或接受新辅助全身或放射治疗的患者。分析人口学和临床变量。采用倾向评分匹配(PSM)来调整行节段切除术患者与未行术前活检患者之间的混杂因素。比较两组患者的短期结局(再入院、30天和90天生存期)和长期总生存期(OS)。结果:6891例患者符合纳入标准,其中术前活检2287例(33.2%),未行活检4604例(66.8%)。30天再入院(P = 0.13)、30天生存率(P = 0.26)和90天生存率(P = 0.31)无显著差异。术前未接受活检的患者5年OS较高(P = 0.02);psm后,两组间差异无统计学意义(P = 0.20)。结论:PSM后,两组患者在切缘阳性、淋巴结占上风、30天再入院、30天和90天生存以及5年OS方面无显著差异。这表明对于早期≤2cm的非小细胞肺癌患者,不进行术前活检的节段切除术仍然是一种安全的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical lung cancer
Clinical lung cancer 医学-肿瘤学
CiteScore
7.00
自引率
2.80%
发文量
159
审稿时长
24 days
期刊介绍: Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
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