The Effect of Ulinastatin on Sepsis Outcomes: An Umbrella Review of Meta-Analysis

IF 3.2 4区医学 Q2 PHARMACOLOGY & PHARMACY

Clinical therapeutics Pub Date : 2025-03-06 DOI:10.1016/j.clinthera.2025.01.013

Sheng Cao PharmD, Ping Han PharmD

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引用次数: 0

Abstract

Objectives

Sepsis, a multifaceted disorder, emerges from dysregulated host response to infection, culminating in organ dysfunction and heightened risk of mortality. Present umbrella systematic review was conducted to impart accurate data regarding the effect of urinary trypsin inhibitor (UTI) alone, UTI in combination with thymosin α1, and UTI in combination with Xuebijing on sepsis and inflammation, 28-day mortality rate survival day, time of mechanical ventilation, length of intensive care unit stay, and acute physiology and chronic health evaluation (APACHE II) score.

Methods

Relevant studies were searched in international databases, including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central Library up to March 2024. Our study included meta-analyses that evaluated the effects of ulinastatin (UTI) alone, or in combination with thymosin α1 or Xuebijing, on sepsis and inflammatory biomarkers.

Results

Nine studies were deemed relevant and subsequently included in the study. The age of the study's participants was between 42.3 and 55.7 years. In total, the dose varied between 166 and 570 KIU/12 h. Moreover, the duration varied between 3 and 8.5 days.

Conclusion

A comprehensive assessment of ulinastatin's overall efficacy necessitates a careful consideration of the combined effects of ulinastatin with other interventions. Future research is warranted to disentangle the specific contributions of ulinastatin in combination therapies and to enhance our understanding of its independent effects in clinical settings.

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来源期刊

Clinical therapeutics 医学-药学

CiteScore

6.00

自引率

3.10%

发文量

154

审稿时长

9 weeks

期刊介绍： Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.