After-hours surgery: concerns in confounders and conclusion – a reply

IF 7.5 1区医学 Q1 ANESTHESIOLOGY

Anaesthesia Pub Date : 2025-03-09 DOI:10.1111/anae.16593

Tak Kyu Oh, In-Ae Song

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引用次数: 0

Abstract

We thank Sakurai and Takeda [1] for their interest in our study [2]. It is inevitable there will be confounding variables present in a retrospective, large-scale population-based, cohort study. Ultimately, we assert that effective reflection on and control of confounding variables enhances the reliability of the study findings.

Initially, it was necessary to incorporate the emergency surgery group to guarantee a sufficiently large after-hours cohort; this clearly represents a constraint. We tried to enhance the reliability of our findings by accounting for the complexity and risk associated with the surgical procedures, referred to as ‘total relative value unit’. We trust this addresses the concerns regarding the absence of information on surgical procedures.

Regarding the absolute standardised mean difference calculation, we have verified that 0.071 is accurate. The calculation of absolute standardised mean difference clearly considers the substantial numbers of patients (very large in our study), the 1:5 matching ratio and the 0.25 matching calliper. We consulted our statistician regarding the varying outcomes from the formula by Sakurai and Takeda [1], and they indicated that it is improbable that all factors were considered.

In summary, we acknowledge that there are constraints to our findings. There appears to be significant potential for additional investigation.

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下班后手术：混杂因素和结论——一个答复

我们感谢Sakurai和Takeda[1]对我们的研究[1]的兴趣。在回顾性、大规模人群为基础的队列研究中，不可避免地会出现混杂变量。最后，我们认为对混杂变量的有效反思和控制提高了研究结果的可靠性。最初，有必要纳入急诊手术组，以保证足够大的下班后队列；这显然是一种约束。我们试图通过考虑与手术过程相关的复杂性和风险（称为“总相对价值单位”）来提高我们发现的可靠性。我们相信这解决了关于缺乏外科手术信息的问题。对于绝对标准化均差计算，我们已经验证了0.071是准确的。绝对标准化平均差的计算清楚地考虑了大量的患者（在我们的研究中非常大），1:5的匹配比和0.25的匹配卡尺。我们咨询了我们的统计学家关于Sakurai和Takeda b[1]公式的不同结果，他们表示不可能考虑所有因素。总之，我们承认我们的研究结果存在局限性。看来进行进一步调查的可能性很大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaesthesia 医学-麻醉学

CiteScore

21.20

自引率

9.30%

发文量

300

审稿时长

6 months

期刊介绍： The official journal of the Association of Anaesthetists is Anaesthesia. It is a comprehensive international publication that covers a wide range of topics. The journal focuses on general and regional anaesthesia, as well as intensive care and pain therapy. It includes original articles that have undergone peer review, covering all aspects of these fields, including research on equipment.